Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous and challenging. Over the past decades, there has been an increasing body of literature related to the effects of secondary metabolites from...

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Published inMolecules (Basel, Switzerland) Vol. 26; no. 14; p. 4333
Main Authors Shehadeh, Mayadah Bashir, Suaifan, Ghadeer A. R. Y., Abu-Odeh, Ala’ Mustafa
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 17.07.2021
MDPI
Subjects
alkaloids
AMP-activated protein kinase
Anthocyanins
Antidiabetics
Apoptosis
Beta cells
Carbohydrate metabolism
Carbohydrates
Chemical compounds
coumarins
Diabetes
Diabetes mellitus
Enzymes
Fatty acids
FDA approval
Flavonoids
Gene expression
Glucagon
Glucose
Herbal medicine
Homeostasis
Hyperglycemia
Insulin
insulin signal
Kinases
Liver
Metabolic pathways
Metabolism
Metabolites
Molecular modelling
Natural products
Oxidative stress
Pancreas
Peptides
Pharmacology
Phenols
Phosphatase
Polysaccharides
Potassium
Proteins
Review
Saccharides
Saponins
Secondary metabolites
Signal transduction
Small intestine
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Abstract Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous and challenging. Over the past decades, there has been an increasing body of literature related to the effects of secondary metabolites from botanical sources on diabetes. Plants-derived metabolites including alkaloids, phenols, anthocyanins, flavonoids, stilbenoids, saponins, tannins, polysaccharides, coumarins, and terpenes can target cellular and molecular mechanisms involved in carbohydrate metabolism. In addition, they can grant protection to pancreatic beta cells from damage, repairing abnormal insulin signaling, minimizing oxidative stress and inflammation, activating AMP-activated protein kinase (AMPK), and inhibiting carbohydrate digestion and absorption. Studies have highlighted many bioactive naturally occurring plants’ secondary metabolites as candidates against diabetes. This review summarizes the current knowledge compiled from the latest studies published during the past decade on the mechanism-based action of plants-derived secondary metabolites that can target various metabolic pathways in humans against diabetes. It is worth mentioning that the compiled data in this review will provide a guide for researchers in the field, to develop candidates into environment-friendly effective, yet safe antidiabetics.
AbstractList Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous and challenging. Over the past decades, there has been an increasing body of literature related to the effects of secondary metabolites from botanical sources on diabetes. Plants-derived metabolites including alkaloids, phenols, anthocyanins, flavonoids, stilbenoids, saponins, tannins, polysaccharides, coumarins, and terpenes can target cellular and molecular mechanisms involved in carbohydrate metabolism. In addition, they can grant protection to pancreatic beta cells from damage, repairing abnormal insulin signaling, minimizing oxidative stress and inflammation, activating AMP-activated protein kinase (AMPK), and inhibiting carbohydrate digestion and absorption. Studies have highlighted many bioactive naturally occurring plants’ secondary metabolites as candidates against diabetes. This review summarizes the current knowledge compiled from the latest studies published during the past decade on the mechanism-based action of plants-derived secondary metabolites that can target various metabolic pathways in humans against diabetes. It is worth mentioning that the compiled data in this review will provide a guide for researchers in the field, to develop candidates into environment-friendly effective, yet safe antidiabetics.
Author Abu-Odeh, Ala’ Mustafa
Shehadeh, Mayadah Bashir
Suaifan, Ghadeer A. R. Y.
AuthorAffiliation Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman 11942, Jordan; gh.suaifan@ju.edu.jo (G.A.R.Y.S.); alaabuodeh82@gmail.com (A.M.A.-O.)
AuthorAffiliation_xml – name: Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman 11942, Jordan; gh.suaifan@ju.edu.jo (G.A.R.Y.S.); alaabuodeh82@gmail.com (A.M.A.-O.)
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Snippet Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous...
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SubjectTerms alkaloids
AMP-activated protein kinase
Anthocyanins
Antidiabetics
Apoptosis
Beta cells
Carbohydrate metabolism
Carbohydrates
Chemical compounds
coumarins
Diabetes
Diabetes mellitus
Enzymes
Fatty acids
FDA approval
Flavonoids
Gene expression
Glucagon
Glucose
Herbal medicine
Homeostasis
Hyperglycemia
Insulin
insulin signal
Kinases
Liver
Metabolic pathways
Metabolism
Metabolites
Molecular modelling
Natural products
Oxidative stress
Pancreas
Peptides
Pharmacology
Phenols
Phosphatase
Polysaccharides
Potassium
Proteins
Review
Saccharides
Saponins
Secondary metabolites
Signal transduction
Small intestine
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Title Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
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https://search.proquest.com/docview/2555114217
https://pubmed.ncbi.nlm.nih.gov/PMC8307461
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Volume 26
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