Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection

• Published in: British journal of cancer Vol. 123; no. 1; pp. 92 - 100
• Main Authors: Liu, Wei-Ren, Tian, Meng-Xin, Tang, Zheng, Fang, Yuan, Zhou, Yu-Fu, Song, Shu-Shu, Jiang, Xi-Fei, Wang, Han, Tao, Chen-Yang, Zhou, Pei-Yun, Qu, Wei-Feng, Ding, Zhen-Bin, Peng, Yuan-Fei, Zhou, Jian, Fan, Jia, Shi, Ying-Hong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.07.2020; Nature Publishing Group
• Subjects: 692/4028/67/1504/1610/4029; 692/53/2422; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Decision making; Disease-Free Survival; Drug Resistance; Epidemiology; Female; Gene Expression Regulation, Neoplastic - genetics; Hepatocellular carcinoma; Humans; Immunohistochemistry; Immunohistochemistry - methods; Liver cancer; Liver Neoplasms - diagnosis; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Male; Middle Aged; Molecular Medicine; Neoplasm Proteins - genetics; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Nomograms; Oncology; Patients; Prognosis; Proportional Hazards Models; Survival; Survival Rate; Transcriptome - genetics

Background Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. Methods The immunohistochemistry (IHC...