NiH-catalysed proximal-selective hydroalkylation of unactivated alkenes and the ligand effects on regioselectivity

• Published in: Nature communications Vol. 13; no. 1; pp. 1890 - 10
• Main Authors: Wang, Xiao-Xu, Xu, Yuan-Tai, Zhang, Zhi-Lin, Lu, Xi, Fu, Yao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 140/131; 140/58; 639/638/403/933; 639/638/403/934; 639/638/77/888; Alkenes; Amines; Aminoquinolines; Bromides; Carboxylic acids; Catalysis; Catalysts; Chemical reactions; Computer applications; Coupling (molecular); Cross coupling; Functional groups; Humanities and Social Sciences; Iodides; Ligands; multidisciplinary; Nickel; Nickel chloride; Nucleophiles; Organic chemistry; Reaction mechanisms; Regioselectivity; Science; Science (multidisciplinary)

Alkene hydrocarbonation reactions have been developed to supplement traditional electrophile-nucleophile cross-coupling reactions. The branch-selective hydroalkylation method applied to a broad range of unactivated alkenes remains challenging. Herein, we report a NiH-catalysed proximal-selective hyd...