Oestrogen receptor-regulated glutathione S-transferase mu 3 expression attenuates hydrogen peroxide-induced cytotoxicity, which confers tamoxifen resistance on breast cancer cells

• Published in: Breast cancer research and treatment Vol. 172; no. 1; pp. 45 - 59
• Main Authors: Lin, Juo-Han, Tu, Shih-Hsin, Chen, Li-Ching, Huang, Chi-Cheng, Chang, Hang-Lung, Cheng, Tzu-Chun, Chang, Hui-Wen, Wu, Chih-Hsiung, Wu, Han-Chung, Ho, Yuan-Soon
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2018; Springer; Springer Nature B.V
• Subjects: Analysis; Animals; Antineoplastic Agents, Hormonal - pharmacology; Apoptosis; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cancer cells; Cancer prevention; Cancer research; Cell proliferation; Cell Proliferation - drug effects; Chromatin; Cytotoxicity; Detoxification; Drug Resistance, Neoplasm - genetics; ErbB-2 protein; Estrogen Receptor alpha - genetics; Estrogens; Estrogens - genetics; Female; Flow cytometry; Gene expression; Gene Expression Regulation, Neoplastic; Gene regulation; Genes; Glutathione; Glutathione transferase; Glutathione Transferase - genetics; GSTM3 gene; Humans; Hydrogen peroxide; Hydrogen Peroxide - toxicity; Immunoprecipitation; MCF-7 Cells; Medical schools; Medicine; Medicine & Public Health; Mice; Oncology; Patients; Polymerase chain reaction; Preclinical Study; Reactive Oxygen Species - metabolism; Receptor, ErbB-2 - genetics; RNA; Signal Transduction - drug effects; siRNA; Sp1 protein; Surgery; Tamoxifen; Tamoxifen - pharmacology; Transcription factors; Tumors; Xenograft Model Antitumor Assays; Xenografts; Glutathione S-transferase mu 3; Breast cancer; Hydrogen peroxide; Tamoxifen resistance; Oestrogen receptor

Purpose Glutathione S-transferase mu 3 (GSTM3) is an enzyme involving in the detoxification of electrophilic compounds by conjugation with glutathione. Higher GSTM3 mRNA levels were reported in patients with ERα-positive breast cancer who received only tamoxifen therapy after surgery. Thus, this stu...