Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication

• Published in: Cell death & disease Vol. 10; no. 6; p. 392
• Main Authors: Wan, Chunlei, Tai, Jiahui, Zhang, Jie, Guo, Yi, Zhu, Qing, Ling, Ding, Gu, Feng, Gan, Jin, Zhu, Caixia, Wang, Yuyan, Liu, Sijin, Wei, Fang, Cai, Qiliang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.05.2019; Springer Nature B.V
• Subjects: 101/28; 13/106; 59/5; 631/67/1059/153; 631/67/1858; 64/60; 82/80; 96/2; 96/95; Animals; Antibodies; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell death; Cell Line, Tumor; Cell Proliferation - drug effects; Chemotherapy; Cytotoxicity; Epstein-Barr virus; Herpes viruses; Herpesvirus 4, Human - isolation & purification; Herpesvirus 4, Human - physiology; Herpesvirus 8, Human - isolation & purification; Herpesvirus 8, Human - physiology; Humans; Immunology; Latent infection; Life Sciences; Metal Nanoparticles - chemistry; Metal Nanoparticles - toxicity; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles; Nanotechnology; Neoplasms - pathology; Neoplasms - virology; Phagocytosis; Reactive oxygen species; Reactive Oxygen Species - metabolism; Replication; Sarcoma; Silver; Silver - chemistry; Transplantation, Heterologous; Tumors; Virion - drug effects; Virions; Virus Replication - drug effects; Xenografts

Silver nanoparticle (nAg), which is one of the most common manufactured nanomaterials, has a wide range of biomedical applications. The human oncogenic γ-herpesviruses, Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein–Barr Virus (EBV), are etiologically linked to many malignancies. Current...