Observation versus excision of lobular neoplasia on core needle biopsy of the breast

• Published in: Breast cancer research and treatment Vol. 168; no. 3; pp. 649 - 654
• Main Authors: Schmidt, Hank, Arditi, Brittany, Wooster, Margaux, Weltz, Christina, Margolies, Laurie, Bleiweiss, Ira, Port, Elisa, Jaffer, Shabnam
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2018; Springer; Springer Nature B.V
• Subjects: Aluminum compounds; Biopsy; Biopsy, Large-Core Needle; Breast; Breast - diagnostic imaging; Breast - pathology; Breast - surgery; Breast cancer; Breast Carcinoma In Situ - diagnosis; Breast Carcinoma In Situ - diagnostic imaging; Breast Carcinoma In Situ - pathology; Breast Carcinoma In Situ - surgery; Cancer research; Clinical Trial; Discordance; Female; Humans; Hyperplasia; Invasiveness; Malignancy; Mammography; Medical schools; Medicine; Medicine & Public Health; Middle Aged; Oncology; Precancerous Conditions - diagnosis; Precancerous Conditions - diagnostic imaging; Precancerous Conditions - genetics; Retrospective Studies; Surgery; Surveillance; Lobular neoplasia; Lobular carcinoma in situ; Atypical lobular hyperplasia

Purpose Controversy surrounds management of lobular neoplasia (LN), [atypical lobular hyperplasia (ALH) or lobular carcinoma in situ (LCIS)], diagnosed on core needle biopsy (CNB). Retrospective series of pure ALH and LCIS reported “upgrade” rate to DCIS or invasive cancer in 0–40%. Few reports docu...