Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma

• Published in: Cancer cell Vol. 38; no. 5; pp. 716 - 733.e6
• Main Authors: Dong, Rui, Yang, Ran, Zhan, Yong, Lai, Hua-Dong, Ye, Chun-Jing, Yao, Xiao-Ying, Luo, Wen-Qin, Cheng, Xiao-Mu, Miao, Ju-Ju, Wang, Jun-Feng, Liu, Bai-Hui, Liu, Xiang-Qi, Xie, Lu-Lu, Li, Yi, Zhang, Man, Chen, Lian, Song, Wei-Chen, Qian, Wei, Gao, Wei-Qiang, Tang, Yun-Hui, Shen, Chun-Yan, Jiang, Wei, Chen, Gong, Yao, Wei, Dong, Kui-Ran, Xiao, Xian-Min, Zheng, Shan, Li, Kai, Wang, Jia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.11.2020
• Subjects: cell differentiation; cell proliferation; cells of origin; chromaffin cells; neural crest cells; neuroblastoma; pediatric cancer; Schwann cell precursors; single-cell RNA sequencing; tumor heterogeneity; single-cell RNA sequencing; neural crest cells; cell differentiation; Schwann cell precursors; chromaffin cells; cell proliferation; neuroblastoma; cells of origin; pediatric cancer; tumor heterogeneity

Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most common extracranial solid tumor occurring in childhood. Despite extensive research, the underlying developmental origin of NB remains unclear. Using single-cell RNA sequencing, we generate transcriptomes of adrena...