Obtaining Precise Molecular Information via DNA Nanotechnology
Precise characterization of biomolecular information such as molecular structures or intermolecular interactions provides essential mechanistic insights into the understanding of biochemical processes. As the resolution of imaging-based measurement techniques improves, so does the quantity of molecu...
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Published in | Membranes (Basel) Vol. 11; no. 9; p. 683 |
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Main Authors | , |
Format | Journal Article |
Language | English |
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02.09.2021
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Abstract | Precise characterization of biomolecular information such as molecular structures or intermolecular interactions provides essential mechanistic insights into the understanding of biochemical processes. As the resolution of imaging-based measurement techniques improves, so does the quantity of molecular information obtained using these methodologies. DNA (deoxyribonucleic acid) molecule have been used to build a variety of structures and dynamic devices on the nanoscale over the past 20 years, which has provided an accessible platform to manipulate molecules and resolve molecular information with unprecedented precision. In this review, we summarize recent progress related to obtaining precise molecular information using DNA nanotechnology. After a brief introduction to the development and features of structural and dynamic DNA nanotechnology, we outline some of the promising applications of DNA nanotechnology in structural biochemistry and in molecular biophysics. In particular, we highlight the use of DNA nanotechnology in determination of protein structures, protein–protein interactions, and molecular force. |
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AbstractList | Precise characterization of biomolecular information such as molecular structures or intermolecular interactions provides essential mechanistic insights into the understanding of biochemical processes. As the resolution of imaging-based measurement techniques improves, so does the quantity of molecular information obtained using these methodologies. DNA (deoxyribonucleic acid) molecule have been used to build a variety of structures and dynamic devices on the nanoscale over the past 20 years, which has provided an accessible platform to manipulate molecules and resolve molecular information with unprecedented precision. In this review, we summarize recent progress related to obtaining precise molecular information using DNA nanotechnology. After a brief introduction to the development and features of structural and dynamic DNA nanotechnology, we outline some of the promising applications of DNA nanotechnology in structural biochemistry and in molecular biophysics. In particular, we highlight the use of DNA nanotechnology in determination of protein structures, protein–protein interactions, and molecular force. |
Author | Tang, Qian Han, Da |
AuthorAffiliation | 1 Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; qtang@sjtu.edu.cn 2 School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China |
AuthorAffiliation_xml | – name: 1 Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; qtang@sjtu.edu.cn – name: 2 School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China |
Author_xml | – sequence: 1 givenname: Qian surname: Tang fullname: Tang, Qian – sequence: 2 givenname: Da surname: Han fullname: Han, Da |
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Copyright | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 by the authors. 2021 |
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SubjectTerms | Automation Biophysics cryo-EM Deoxyribonucleic acid Design DNA DNA nanotechnology molecular forces Molecular structure Nanotechnology Protein interaction Proteins protein–protein interactions Review single-molecule techniques structural reconstruction |
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Title | Obtaining Precise Molecular Information via DNA Nanotechnology |
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