Obtaining Precise Molecular Information via DNA Nanotechnology

Precise characterization of biomolecular information such as molecular structures or intermolecular interactions provides essential mechanistic insights into the understanding of biochemical processes. As the resolution of imaging-based measurement techniques improves, so does the quantity of molecu...

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Published inMembranes (Basel) Vol. 11; no. 9; p. 683
Main Authors Tang, Qian, Han, Da
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 02.09.2021
MDPI
Subjects
Automation
Biophysics
cryo-EM
Deoxyribonucleic acid
Design
DNA
DNA nanotechnology
molecular forces
Molecular structure
Nanotechnology
Protein interaction
Proteins
protein–protein interactions
Review
single-molecule techniques
structural reconstruction
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Abstract Precise characterization of biomolecular information such as molecular structures or intermolecular interactions provides essential mechanistic insights into the understanding of biochemical processes. As the resolution of imaging-based measurement techniques improves, so does the quantity of molecular information obtained using these methodologies. DNA (deoxyribonucleic acid) molecule have been used to build a variety of structures and dynamic devices on the nanoscale over the past 20 years, which has provided an accessible platform to manipulate molecules and resolve molecular information with unprecedented precision. In this review, we summarize recent progress related to obtaining precise molecular information using DNA nanotechnology. After a brief introduction to the development and features of structural and dynamic DNA nanotechnology, we outline some of the promising applications of DNA nanotechnology in structural biochemistry and in molecular biophysics. In particular, we highlight the use of DNA nanotechnology in determination of protein structures, protein–protein interactions, and molecular force.
AbstractList Precise characterization of biomolecular information such as molecular structures or intermolecular interactions provides essential mechanistic insights into the understanding of biochemical processes. As the resolution of imaging-based measurement techniques improves, so does the quantity of molecular information obtained using these methodologies. DNA (deoxyribonucleic acid) molecule have been used to build a variety of structures and dynamic devices on the nanoscale over the past 20 years, which has provided an accessible platform to manipulate molecules and resolve molecular information with unprecedented precision. In this review, we summarize recent progress related to obtaining precise molecular information using DNA nanotechnology. After a brief introduction to the development and features of structural and dynamic DNA nanotechnology, we outline some of the promising applications of DNA nanotechnology in structural biochemistry and in molecular biophysics. In particular, we highlight the use of DNA nanotechnology in determination of protein structures, protein–protein interactions, and molecular force.
Author Tang, Qian
Han, Da
AuthorAffiliation 1 Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; qtang@sjtu.edu.cn
2 School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
AuthorAffiliation_xml – name: 1 Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; qtang@sjtu.edu.cn
– name: 2 School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
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  givenname: Qian
  surname: Tang
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  givenname: Da
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SubjectTerms Automation
Biophysics
cryo-EM
Deoxyribonucleic acid
Design
DNA
DNA nanotechnology
molecular forces
Molecular structure
Nanotechnology
Protein interaction
Proteins
protein–protein interactions
Review
single-molecule techniques
structural reconstruction
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Title Obtaining Precise Molecular Information via DNA Nanotechnology
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