Flux sampling is a powerful tool to study metabolism under changing environmental conditions

• Published in: NPJ systems biology and applications Vol. 5; no. 1; pp. 32 - 8
• Main Authors: Herrmann, Helena A., Dyson, Beth C., Vass, Lucy, Johnson, Giles N., Schwartz, Jean-Marc
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.09.2019; Nature Publishing Group
• Subjects: 631/449; 631/553/2710; Acclimation; Acclimatization - genetics; Acclimatization - physiology; Adaptation, Physiological - genetics; Adaptation, Physiological - physiology; Algorithms; Arabidopsis - genetics; Arabidopsis - metabolism; Bioinformatics; Biomedical and Life Sciences; Cold acclimation; Cold Temperature; Cold-Shock Response - physiology; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Computer Simulation; Diurnal; Environmental conditions; Genome; Genomes; Life Sciences; Metabolic flux; Metabolic Flux Analysis - methods; Metabolic networks; Metabolic Networks and Pathways - genetics; Metabolic Networks and Pathways - physiology; Metabolism; Models, Biological; Plant Leaves - metabolism; Sampling; Starch; Systems Biology; Biochemical networks; Plant sciences

The development of high-throughput ‘omic techniques has sparked a rising interest in genome-scale metabolic models, with applications ranging from disease diagnostics to crop adaptation. Efficient and accurate methods are required to analyze large metabolic networks. Flux sampling can be used to exp...