Toll like receptors in self-recovering hepatitis E patients with or without pregnancy

• Published in: Human immunology Vol. 75; no. 12; pp. 1147 - 1154
• Main Authors: Arya, Ravi P., Arankalle, Vidya A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2014
• Subjects: Allergy and Immunology; Cells, Cultured; Cytokines - immunology; Female; Hepatitis E; Hepatitis E - immunology; Hepatitis E virus - immunology; Humans; Interferon-beta - biosynthesis; Interferon-beta - immunology; Interferon-gamma - biosynthesis; Interferon-gamma - immunology; MyD-dependent pathway; Myeloid Differentiation Factor 88 - immunology; Pregnancy; Pregnancy Complications, Infectious; Signal Transduction - immunology; Toll like receptors; Toll-Like Receptors - blood; Toll-Like Receptors - genetics; Toll-Like Receptors - immunology; TRIF mediated pathway; Hepatitis E; IL; poly I:C; Toll like receptors; NFkB; R848; TNF; LPS; IFN; Pregnancy; IRAK; IkBα; TBK1; ANC; TRIF mediated pathway; MyD-dependent pathway; HEV; TLR; IRF; polyinosinic:polycytidylic acid; hepatitis E virus; Antenatal care (pregnancy); TANK-binding kinase 1; interleukin; nuclear factor kappa-light-chain-enhancer of activated B cells; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; interferon regulatory transcription factor; interleukin-1 receptor-associated kinase; TLR7/8-ligand; interferon; tumor necrosis factor; lipopolysaccharide

Hepatitis E virus (HEV) causes high mortality among pregnant women. Pathogenesis of HEV, especially during pregnancy, is poorly understood. Our aim was to assess the role of Toll-like-receptors (TLRs) in hepatitis E patients with pregnancy (Antenatal care, ANC) or without pregnancy (non-ANC). The pa...