A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?

Cardiovascular diseases are the leading cause of death worldwide. Research in the last two decades has emphasized the inflammatory process as a key component in the pathogenesis of many of them. The Interleukin-1 family is a pivotal element of inflammation and has been well studied as a therapeutic...

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Published inCardiology and therapy Vol. 7; no. 1; pp. 25 - 44
Main Authors Szekely, Yishay, Arbel, Yaron
Format Journal Article
LanguageEnglish
Published Cheshire Springer Healthcare 01.06.2018
Springer Nature B.V
Subjects
Cardiology
Cytokines
Internal Medicine
Medicine
Medicine & Public Health
Monoclonal antibodies
Review
Sepsis
Heart failure
Myocardial infarction
Myocarditis
Pericarditis
Interleukin-1
Arrhythmia
Sepsis-induced cardiomyopathy
Canakinumab
Anakinra
Online AccessGet full text

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Abstract Cardiovascular diseases are the leading cause of death worldwide. Research in the last two decades has emphasized the inflammatory process as a key component in the pathogenesis of many of them. The Interleukin-1 family is a pivotal element of inflammation and has been well studied as a therapeutic target in various inflammatory states. Recent trials have explored the effect of Interleukin-1 blockade in cardiovascular diseases and initial evidence of the relevance of such treatment in this field of medicine accumulate. This review will describe the role of Interleukin-1 in heart diseases and the potential therapeutic effect of its blockade in such diseases.
AbstractList Cardiovascular diseases are the leading cause of death worldwide. Research in the last two decades has emphasized the inflammatory process as a key component in the pathogenesis of many of them. The Interleukin-1 family is a pivotal element of inflammation and has been well studied as a therapeutic target in various inflammatory states. Recent trials have explored the effect of Interleukin-1 blockade in cardiovascular diseases and initial evidence of the relevance of such treatment in this field of medicine accumulate. This review will describe the role of Interleukin-1 in heart diseases and the potential therapeutic effect of its blockade in such diseases.
Cardiovascular diseases are the leading cause of death worldwide. Research in the last two decades has emphasized the inflammatory process as a key component in the pathogenesis of many of them. The Interleukin-1 family is a pivotal element of inflammation and has been well studied as a therapeutic target in various inflammatory states. Recent trials have explored the effect of Interleukin-1 blockade in cardiovascular diseases and initial evidence of the relevance of such treatment in this field of medicine accumulate. This review will describe the role of Interleukin-1 in heart diseases and the potential therapeutic effect of its blockade in such diseases.Cardiovascular diseases are the leading cause of death worldwide. Research in the last two decades has emphasized the inflammatory process as a key component in the pathogenesis of many of them. The Interleukin-1 family is a pivotal element of inflammation and has been well studied as a therapeutic target in various inflammatory states. Recent trials have explored the effect of Interleukin-1 blockade in cardiovascular diseases and initial evidence of the relevance of such treatment in this field of medicine accumulate. This review will describe the role of Interleukin-1 in heart diseases and the potential therapeutic effect of its blockade in such diseases.
Author Arbel, Yaron
Szekely, Yishay
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/29417406$$D View this record in MEDLINE/PubMed
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Copyright The Author(s) 2018
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Issue 1
Keywords Heart failure
Myocardial infarction
Myocarditis
Pericarditis
Interleukin-1
Arrhythmia
Sepsis-induced cardiomyopathy
Canakinumab
Anakinra
Language English
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Snippet Cardiovascular diseases are the leading cause of death worldwide. Research in the last two decades has emphasized the inflammatory process as a key component...
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SubjectTerms Cardiology
Cytokines
Internal Medicine
Medicine
Medicine & Public Health
Monoclonal antibodies
Review
Sepsis
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Title A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?
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