Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality

Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher...

Full description

Saved in:
Bibliographic Details
Published inMucosal immunology Vol. 12; no. 2; pp. 545 - 554
Main Authors Kulkarni, Upasana, Zemans, Rachel L., Smith, Candice A., Wood, Sherri C., Deng, Jane C., Goldstein, Daniel R.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.03.2019
Elsevier Limited
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher levels of lung neutrophils than younger mice after influenza viral infection. Depleting neutrophils after, but not before, infection substantially improves the survival of aged mice without altering viral clearance. Aged alveolar epithelial cells (AECs) have a higher frequency of senescence and secrete higher levels of the neutrophil-attracting chemokines CXCL1 and CXCL2 during influenza infection. These chemokines are required for age-enhanced neutrophil chemotaxis in vitro. Our work suggests that aging increases mortality from influenza in part because senescent AECs secrete more chemokines, leading to excessive neutrophil recruitment. Therapies that mitigate this pathological immune response in the elderly might improve outcomes of influenza and other respiratory infections.
AbstractList Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here, we show that aged mice have higher levels of lung neutrophils than younger mice after influenza viral infection. Depleting neutrophils after, but not before, infection substantially improves the survival of aged mice without altering viral clearance. Aged alveolar epithelial cells (AECs) have a higher frequency of senescence and secrete higher levels of the neutrophil-attracting chemokines CXCL1 and CXCL2 during influenza infection. These chemokines are required for age-enhanced neutrophil chemotaxis in vitro . Our work suggests that aging increases mortality from influenza in part because senescent AECs secrete more chemokines, leading to excessive neutrophil recruitment. Therapies that mitigate this pathological immune response in the elderly might improve outcomes of influenza and other respiratory infections.
Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher levels of lung neutrophils than younger mice after influenza viral infection. Depleting neutrophils after, but not before, infection substantially improves the survival of aged mice without altering viral clearance. Aged alveolar epithelial cells (AECs) have a higher frequency of senescence and secrete higher levels of the neutrophil-attracting chemokines CXCL1 and CXCL2 during influenza infection. These chemokines are required for age-enhanced neutrophil chemotaxis in vitro. Our work suggests that aging increases mortality from influenza in part because senescent AECs secrete more chemokines, leading to excessive neutrophil recruitment. Therapies that mitigate this pathological immune response in the elderly might improve outcomes of influenza and other respiratory infections.
Author Deng, Jane C.
Wood, Sherri C.
Kulkarni, Upasana
Smith, Candice A.
Goldstein, Daniel R.
Zemans, Rachel L.
AuthorAffiliation 2 Institute of Gerontology, University of Michigan
1 Department of Internal Medicine, University of Michigan
3 Department of Microbiology and Immunology, University of Michigan
AuthorAffiliation_xml – name: 1 Department of Internal Medicine, University of Michigan
– name: 2 Institute of Gerontology, University of Michigan
– name: 3 Department of Microbiology and Immunology, University of Michigan
Author_xml – sequence: 1
  givenname: Upasana
  surname: Kulkarni
  fullname: Kulkarni, Upasana
  organization: Department of Internal Medicine, University of Michigan
– sequence: 2
  givenname: Rachel L.
  surname: Zemans
  fullname: Zemans, Rachel L.
  organization: Department of Internal Medicine, University of Michigan
– sequence: 3
  givenname: Candice A.
  surname: Smith
  fullname: Smith, Candice A.
  organization: Department of Internal Medicine, University of Michigan
– sequence: 4
  givenname: Sherri C.
  surname: Wood
  fullname: Wood, Sherri C.
  organization: Department of Internal Medicine, University of Michigan
– sequence: 5
  givenname: Jane C.
  surname: Deng
  fullname: Deng, Jane C.
  organization: Department of Internal Medicine, University of Michigan
– sequence: 6
  givenname: Daniel R.
  surname: Goldstein
  fullname: Goldstein, Daniel R.
  email: drgoldst@umich.edu
  organization: Department of Internal Medicine, University of Michigan, Institute of Gerontology, University of Michigan, Department of Microbiology and Immunology, University of Michigan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30617300$$D View this record in MEDLINE/PubMed
BookMark eNp1kU1rHDEMhk1JaT7aH9BLGegll2lle2zPXAolpB8Q6CU5G61Hu-vgtbf2zNL018ebTdMP6MFYSI9eSbyn7CimSIy95vCOg-zfl47LXrXA-_q4auUzdsIHWYNO6aOHWLYg-HDMTku5BdAASr5gxxI0NxLghLnLH45K8TtqIs1TTtu1D02gHYXS-NhMa2rCHFfNHEfKwdNDBlfUYinJeZxorJzLhIX2DT4uw0zxJzablCcMfrp7yZ4vMRR69fifsZtPl9cXX9qrb5-_Xny8al1nYGoXcqmNFCMuQAmFBBLIjX3NOViYwZBGg06QGEasqNbKOSlJDaLXOHRKnrEPB93tvNjQ6ChOGYPdZr_BfGcTevt3Jfq1XaWd1dIo03dV4PxRIKfvM5XJbnxxFAJGSnOxgmsFdZ7hFX37D3qb5hzreZWqywrTD32l-IFyOZWSafm0DAe7t9AeLLTVQru30Mra8-bPK546fnlWAXEASi3FFeXfo_-veg_7q6pr
CitedBy_id crossref_primary_10_1183_13993003_02708_2020
crossref_primary_10_3389_fcimb_2023_1098712
crossref_primary_10_1172_jci_insight_172140
crossref_primary_10_1128_IAI_00653_20
crossref_primary_10_1177_15353702231199082
crossref_primary_10_1007_s00018_021_03768_z
crossref_primary_10_3389_fpubh_2021_773130
crossref_primary_10_3390_cells12151981
crossref_primary_10_3390_ijms21030851
crossref_primary_10_1016_j_mucimm_2024_06_010
crossref_primary_10_1038_s41467_023_39569_0
crossref_primary_10_1016_j_mam_2021_100996
crossref_primary_10_1016_j_joim_2022_01_006
crossref_primary_10_1007_s00281_020_00824_x
crossref_primary_10_1042_CS20210879
crossref_primary_10_3389_fimmu_2021_660865
crossref_primary_10_1111_imr_13153
crossref_primary_10_1126_sciimmunol_abc4557
crossref_primary_10_1371_journal_ppat_1010734
crossref_primary_10_1186_s12979_024_00441_4
crossref_primary_10_1038_s41598_020_57969_w
crossref_primary_10_1172_JCI171002
crossref_primary_10_1038_s41385_021_00397_4
crossref_primary_10_1080_21505594_2022_2120951
crossref_primary_10_1371_journal_ppat_1008334
crossref_primary_10_3390_vaccines10111894
crossref_primary_10_3390_biomedicines12061246
crossref_primary_10_1097_QCO_0000000000000538
crossref_primary_10_1186_s12979_022_00321_9
crossref_primary_10_1002_jmv_27102
crossref_primary_10_3390_cells12131708
crossref_primary_10_3390_cells10030708
crossref_primary_10_4049_jimmunol_2000380
crossref_primary_10_1002_JLB_1MR1221_345R
crossref_primary_10_1038_s41467_023_42021_y
crossref_primary_10_1016_j_jaci_2022_12_004
crossref_primary_10_1016_j_ijid_2020_05_068
crossref_primary_10_1016_j_jointm_2022_08_005
crossref_primary_10_1016_j_ceh_2023_06_001
crossref_primary_10_3390_vaccines9060597
crossref_primary_10_1080_21505594_2021_1939608
crossref_primary_10_1016_j_coviro_2020_09_007
crossref_primary_10_1128_IAI_00471_20
crossref_primary_10_1080_19490976_2021_1966255
crossref_primary_10_3389_fimmu_2023_1112870
crossref_primary_10_1111_imr_13171
crossref_primary_10_1186_s12979_024_00442_3
crossref_primary_10_1093_cvr_cvab309
crossref_primary_10_3389_fimmu_2023_1241323
crossref_primary_10_1161_ATVBAHA_120_314514
crossref_primary_10_1002_adhm_202101534
crossref_primary_10_1016_j_celrep_2022_111002
crossref_primary_10_1186_s13578_021_00624_2
crossref_primary_10_3389_fimmu_2022_1089064
crossref_primary_10_1172_jci_insight_156320
crossref_primary_10_3389_fcimb_2020_563850
crossref_primary_10_1016_j_healun_2021_04_017
crossref_primary_10_3389_fimmu_2022_888415
crossref_primary_10_1016_j_cell_2021_03_005
crossref_primary_10_1146_annurev_immunol_101921_040450
crossref_primary_10_3390_ijms24010205
crossref_primary_10_1080_09553002_2020_1683642
crossref_primary_10_3389_fimmu_2021_724618
crossref_primary_10_1001_jamanetworkopen_2020_10895
crossref_primary_10_1183_16000617_0266_2023
crossref_primary_10_1002_hsr2_1085
crossref_primary_10_1016_j_immuni_2021_04_025
crossref_primary_10_1073_pnas_2300474120
crossref_primary_10_7554_eLife_65762
crossref_primary_10_1111_acel_13783
crossref_primary_10_3389_fcell_2022_932723
crossref_primary_10_1016_j_ajpath_2023_12_008
Cites_doi 10.1126/science.1195491
10.1016/j.chom.2017.03.002
10.1172/JCI28508
10.1093/aje/kwx334
10.1016/j.ajpath.2011.03.013
10.1007/978-1-4939-2074-7_27
10.1002/art.24959
10.1016/j.it.2009.03.012
10.1038/nrd.2016.39
10.1073/pnas.1019378108
10.1183/13993003.02367-2016
10.1002/jlb.67.1.40
10.1136/gutjnl-2015-309728
10.2337/db14-1820
10.1152/ajplung.00344.2017
10.1111/acel.12222
10.1016/j.bbrc.2018.04.115
10.1001/jama.294.21.2712
10.1126/science.aaa4352
10.1126/science.aaf3926
10.1038/nprot.2009.191
10.1172/JCI64098
10.1016/j.immuni.2012.09.020
10.1371/journal.ppat.1000661
10.1016/j.cell.2008.02.043
10.1038/srep25051
10.1186/1465-9921-10-112
10.1111/j.1440-1843.2006.00800.x
10.1002/eji.200425091
10.1038/nri3547
10.4049/jimmunol.0901709
10.1016/0168-1656(92)90158-6
10.1128/IAI.05493-11
10.1136/thoraxjnl-2017-210010
10.1182/blood-2003-10-3638
10.4049/jimmunol.0900995
10.4049/jimmunol.1103051
10.1089/vim.2006.0101
10.1111/eci.12949
10.1146/annurev-pathol-020712-164023
10.1111/j.1365-2567.2008.02950.x
10.1086/523584
10.1038/nri3600
10.1038/nature11319
10.1186/1465-9921-9-57
10.1016/j.cell.2013.06.013
10.3389/fimmu.2016.00502
10.1001/jama.289.2.179
10.1016/j.ebiom.2017.04.013
10.1186/2046-2395-2-8
10.1016/j.mad.2011.08.005
10.1111/j.1474-9728.2004.00110.x
10.1016/j.it.2010.05.006
10.1016/j.chom.2016.10.003
10.4049/jimmunol.1700397
10.1038/nri.2017.105
10.1182/blood-2013-08-519520
10.3389/fimmu.2014.00508
10.1016/j.mad.2011.03.001
10.1038/nm.2087
10.1038/nm.3893
10.4049/jimmunol.0902497
10.4049/jimmunol.178.12.8148
10.3389/fimmu.2017.00550
10.3389/fimmu.2016.00041
10.4049/jimmunol.154.10.5411
10.2807/ese.15.20.19571-en
ContentType Journal Article
Copyright Society for Mucosal Immunology 2019
Copyright Nature Publishing Group Mar 2019
Copyright_xml – notice: Society for Mucosal Immunology 2019
– notice: Copyright Nature Publishing Group Mar 2019
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7T5
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.1038/s41385-018-0115-3
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Immunology Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
Medical Database
Biological Science Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE

ProQuest Central Student
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1935-3456
EndPage 554
ExternalDocumentID 10_1038_s41385_018_0115_3
30617300
Genre Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIA NIH HHS
  grantid: R01 AG028082
– fundername: NIA NIH HHS
  grantid: K07 AG050096
– fundername: NHLBI NIH HHS
  grantid: R01 HL131608
– fundername: NIA NIH HHS
  grantid: P30 AG024824
– fundername: NIA NIH HHS
  grantid: T32 AG062403
– fundername: NHLBI NIH HHS
  grantid: R01 HL108949
GroupedDBID ---
-Q-
.1-
.FO
0R~
0SF
123
29M
39C
3V.
4.4
53G
70F
7X7
88E
8FI
8FJ
AALRI
AANZL
AAWBL
AAXUO
AAZLF
ABAWZ
ABDBF
ABUWG
ACGFS
ACKTT
ACRQY
ACZOJ
ADBBV
ADHDB
ADVLN
AEFQL
AEJRE
AENEX
AEXQZ
AEXYK
AFCTW
AFJKZ
AFKRA
AFRHN
AFSHS
AGAYW
AGEZK
AGHAI
AHMBA
AHSBF
AILAN
AITUG
AJRNO
AJUYK
AKRWK
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
AMYLF
AXYYD
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CAG
CCPQU
COF
CS3
DNIVK
DU5
EBS
EE.
EIOEI
EJD
ESX
F5P
FDB
FDQFY
FERAY
FIZPM
FSGXE
FYUFA
HCIFZ
HZ~
IWAJR
JSO
M1P
M7P
NAO
NQJWS
O9-
OK1
P2P
PQQKQ
PROAC
PSQYO
RNT
RNTTT
ROL
SNX
SNYQT
SRMVM
SV3
SWTZT
TAOOD
TBHMF
TDRGL
TSG
UKHRP
Z5R
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
HMCUK
7T5
7XB
8FE
8FH
8FK
AZQEC
DWQXO
GNUQQ
H94
K9.
LK8
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c470t-b3f6732dab0525ae030ecd8673c0b797e6a7ac2e29da3f6665cc33e59286a9453
IEDL.DBID BENPR
ISSN 1933-0219
IngestDate Tue Sep 17 21:16:57 EDT 2024
Fri Oct 25 22:45:01 EDT 2024
Wed Oct 16 13:54:52 EDT 2024
Thu Sep 26 17:35:16 EDT 2024
Wed Oct 16 00:40:13 EDT 2024
Fri Oct 11 20:47:33 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c470t-b3f6732dab0525ae030ecd8673c0b797e6a7ac2e29da3f6665cc33e59286a9453
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
U.K. and D.R.G. conceived and designed the experiments. U.K. performed the experiments with the help of C.S. and S.W. Data analysis was done by U.K. D.R.G wrote the first draft of the paper that was then edited by U.K. All authors subsequently contributed in writing and carefully reviewing the experiments and the manuscript.
Author Contributions
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC6375784
PMID 30617300
PQID 2179727898
PQPubID 2041940
PageCount 10
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6375784
proquest_miscellaneous_2165059271
proquest_journals_2179727898
crossref_primary_10_1038_s41385_018_0115_3
pubmed_primary_30617300
springer_journals_10_1038_s41385_018_0115_3
PublicationCentury 2000
PublicationDate 2019-03-01
PublicationDateYYYYMMDD 2019-03-01
PublicationDate_xml – month: 03
  year: 2019
  text: 2019-03-01
  day: 01
PublicationDecade 2010
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: United States
– name: Kidlington
PublicationSubtitle The official publication of the Society for Mucosal Immunology
PublicationTitle Mucosal immunology
PublicationTitleAbbrev Mucosal Immunol
PublicationTitleAlternate Mucosal Immunol
PublicationYear 2019
Publisher Nature Publishing Group US
Elsevier Limited
Publisher_xml – name: Nature Publishing Group US
– name: Elsevier Limited
References Kovtonyuk, Fritsch, Feng, Manz, Takizawa (CR32) 2016; 7
Legrand (CR37) 1992; 25
Beli (CR8) 2011; 132
Narasaraju (CR33) 2011; 179
Tecchio, Micheletti, Cassatella (CR63) 2014; 5
Lukacs, Strieter, Chensue, Widmer, Kunkel (CR64) 1995; 154
Crowe (CR43) 2009; 183
Mason (CR45) 2006; 11
Iwakura, Ishigame (CR65) 2006; 116
Debacq-Chainiaux, Erusalimsky, Campisi, Toussaint (CR47) 2009; 4
Baylis, Bartlett, Patel, Roberts (CR53) 2013; 2
Lim (CR15) 2015; 349
Lefebvre, Masters, Hopkins, Haynes (CR11) 2016; 6
McDonald (CR14) 2010; 330
Imai (CR23) 2008; 133
Ichinohe (CR57) 2011; 108
Palmer (CR58) 2015; 64
Brandes, Klauschen, Kuchen, Germain Ronald (CR21) 2013; 154
Guo, Callaway, Ting (CR67) 2015; 21
Cowburn, Deighton, Walmsley, Chilvers (CR35) 2004; 34
Toapanta, Ross (CR12) 2009; 10
CR6
Sapey (CR27) 2014; 123
Gurczynski, Moore (CR44) 2018; 314
Biggerstaff (CR4) 2018; 187
Pillai (CR7) 2016; 352
Jiang, Fisher, Murasko (CR9) 2011; 10
Yamamoto (CR34) 2018; 500
Hussell, Bell (CR49) 2014; 14
Chen (CR42) 2016; 20
Clarke (CR55) 2010; 16
Papayannopoulos (CR22) 2017; 18
Thevaranjan (CR29) 2017; 21
Kirkland, Tchkonia (CR68) 2017; 21
Kovacs (CR50) 2009; 30
Furze, Rankin (CR39) 2008; 125
Fullerton, Gilroy (CR24) 2016; 15
CR18
Claesson (CR54) 2012; 488
Tate (CR17) 2009; 183
Werner (CR61) 2011; 79
Williams-Bey, Jiang, Murasko (CR10) 2011; 132
Lehmann (CR59) 2017; 50
Seki (CR19) 2010; 184
Netea (CR36) 2010; 6
Wareing, Shea, Inglis, Dias, Sarawar (CR40) 2007; 20
Tate, Brooks, Reading (CR16) 2008; 9
Maes (CR38) 2015; 1250
Summers (CR13) 2010; 31
Pebody (CR2) 2010; 15
Petty (CR52) 2007; 178
De Filippo., Rankin (CR41) 2018; 0
Peiró (CR20) 2018; 73
Sathaliyawala (CR66) 2013; 38
Tchkonia, Zhu, van Deursen, Campisi, Kirkland (CR46) 2013; 123
Fry, Shay, Holman, Curns, Anderson (CR3) 2005; 294
Mayadas, Cullere, Lowell (CR60) 2014; 9
McGeer (CR48) 2007; 45
Schuijt, Lankelma, Scicluna, de Sousa e Melo, JJTH, de Boer (CR56) 2016; 65
Shaw, Goldstein, Montgomery (CR5) 2013; 13
CR69
Wenisch, Patruta, Daxböck, Krause, Hörl (CR25) 2000; 67
Hazeldine (CR28) 2014; 13
Stout-Delgado, Vaughan, Shirali, Jaramillo, Harrod (CR31) 2012; 188
Fulop (CR26) 2004; 3
Guma (CR62) 2009; 60
Wong (CR30) 2017; 199
Suratt (CR51) 2004; 104
Thompson (CR1) 2003; 289
Mayadas (10.1038/s41385-018-0115-3_bib60) 2014; 9
Chen (10.1038/s41385-018-0115-3_bib42) 2016; 20
Biggerstaff (10.1038/s41385-018-0115-3_bib4) 2018; 187
Baylis (10.1038/s41385-018-0115-3_bib53) 2013; 2
Beli (10.1038/s41385-018-0115-3_bib8) 2011; 132
Tate (10.1038/s41385-018-0115-3_bib16) 2008; 9
Yamamoto (10.1038/s41385-018-0115-3_bib34) 2018; 500
Gurczynski (10.1038/s41385-018-0115-3_bib44) 2018; 314
Mason (10.1038/s41385-018-0115-3_bib45) 2006; 11
Ichinohe (10.1038/s41385-018-0115-3_bib57) 2011; 108
Tchkonia (10.1038/s41385-018-0115-3_bib46) 2013; 123
Guma (10.1038/s41385-018-0115-3_bib62) 2009; 60
10.1038/s41385-018-0115-3_bib69
Papayannopoulos (10.1038/s41385-018-0115-3_bib22) 2017; 18
Williams-Bey (10.1038/s41385-018-0115-3_bib10) 2011; 132
Narasaraju (10.1038/s41385-018-0115-3_bib33) 2011; 179
Tate (10.1038/s41385-018-0115-3_bib17) 2009; 183
Shaw (10.1038/s41385-018-0115-3_bib5) 2013; 13
10.1038/s41385-018-0115-3_bib6
Legrand (10.1038/s41385-018-0115-3_bib37) 1992; 25
Suratt (10.1038/s41385-018-0115-3_bib51) 2004; 104
Cowburn (10.1038/s41385-018-0115-3_bib35) 2004; 34
Crowe (10.1038/s41385-018-0115-3_bib43) 2009; 183
De Filippo. (10.1038/s41385-018-0115-3_bib41) 2018; 0
Claesson (10.1038/s41385-018-0115-3_bib54) 2012; 488
Pebody (10.1038/s41385-018-0115-3_bib2) 2010; 15
Lim (10.1038/s41385-018-0115-3_bib15) 2015; 349
Seki (10.1038/s41385-018-0115-3_bib19) 2010; 184
Furze (10.1038/s41385-018-0115-3_bib39) 2008; 125
Palmer (10.1038/s41385-018-0115-3_bib58) 2015; 64
Hazeldine (10.1038/s41385-018-0115-3_bib28) 2014; 13
McDonald (10.1038/s41385-018-0115-3_bib14) 2010; 330
Wenisch (10.1038/s41385-018-0115-3_bib25) 2000; 67
Debacq-Chainiaux (10.1038/s41385-018-0115-3_bib47) 2009; 4
Kirkland (10.1038/s41385-018-0115-3_bib68) 2017; 21
Lukacs (10.1038/s41385-018-0115-3_bib64) 1995; 154
Fry (10.1038/s41385-018-0115-3_bib3) 2005; 294
Sapey (10.1038/s41385-018-0115-3_bib27) 2014; 123
Maes (10.1038/s41385-018-0115-3_bib38) 2015; 1250
Brandes (10.1038/s41385-018-0115-3_bib21) 2013; 154
Kovtonyuk (10.1038/s41385-018-0115-3_bib32) 2016; 7
Jiang (10.1038/s41385-018-0115-3_bib9) 2011; 10
Stout-Delgado (10.1038/s41385-018-0115-3_bib31) 2012; 188
Werner (10.1038/s41385-018-0115-3_bib61) 2011; 79
Lefebvre (10.1038/s41385-018-0115-3_bib11) 2016; 6
Peiró (10.1038/s41385-018-0115-3_bib20) 2018; 73
Thevaranjan (10.1038/s41385-018-0115-3_bib29) 2017; 21
McGeer (10.1038/s41385-018-0115-3_bib48) 2007; 45
Iwakura (10.1038/s41385-018-0115-3_bib65) 2006; 116
Sathaliyawala (10.1038/s41385-018-0115-3_bib66) 2013; 38
Wareing (10.1038/s41385-018-0115-3_bib40) 2007; 20
Hussell (10.1038/s41385-018-0115-3_bib49) 2014; 14
Pillai (10.1038/s41385-018-0115-3_bib7) 2016; 352
Lehmann (10.1038/s41385-018-0115-3_bib59) 2017; 50
Fulop (10.1038/s41385-018-0115-3_bib26) 2004; 3
Summers (10.1038/s41385-018-0115-3_bib13) 2010; 31
Thompson (10.1038/s41385-018-0115-3_bib1) 2003; 289
Imai (10.1038/s41385-018-0115-3_bib23) 2008; 133
Tecchio (10.1038/s41385-018-0115-3_bib63) 2014; 5
Kovacs (10.1038/s41385-018-0115-3_bib50) 2009; 30
Schuijt (10.1038/s41385-018-0115-3_bib56) 2016; 65
Wong (10.1038/s41385-018-0115-3_bib30) 2017; 199
Fullerton (10.1038/s41385-018-0115-3_bib24) 2016; 15
Guo (10.1038/s41385-018-0115-3_bib67) 2015; 21
Petty (10.1038/s41385-018-0115-3_bib52) 2007; 178
10.1038/s41385-018-0115-3_bib18
Clarke (10.1038/s41385-018-0115-3_bib55) 2010; 16
Toapanta (10.1038/s41385-018-0115-3_bib12) 2009; 10
Netea (10.1038/s41385-018-0115-3_bib36) 2010; 6
References_xml – volume: 330
  start-page: 362
  year: 2010
  end-page: 366
  ident: CR14
  article-title: Intravascular danger signals guide neutrophils to sites of sterile inflammation
  publication-title: Science
  doi: 10.1126/science.1195491
  contributor:
    fullname: McDonald
– volume: 21
  start-page: 455
  year: 2017
  end-page: 466.e454
  ident: CR29
  article-title: Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2017.03.002
  contributor:
    fullname: Thevaranjan
– volume: 116
  start-page: 1218
  year: 2006
  end-page: 1222
  ident: CR65
  article-title: The IL-23/IL-17 axis in inflammation
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI28508
  contributor:
    fullname: Ishigame
– volume: 187
  start-page: 1040
  year: 2018
  end-page: 1050
  ident: CR4
  article-title: Systematic assessment of multiple routine and near real-time indicators to classify the severity of influenza seasons and pandemics in the United States, 2003–2004 through 2015–2016
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwx334
  contributor:
    fullname: Biggerstaff
– volume: 179
  start-page: 199
  year: 2011
  end-page: 210
  ident: CR33
  article-title: Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2011.03.013
  contributor:
    fullname: Narasaraju
– volume: 1250
  start-page: 349
  year: 2015
  end-page: 361
  ident: CR38
  article-title: Measurement of apoptotic and necrotic cell death in primary hepatocyte cultures
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-2074-7_27
  contributor:
    fullname: Maes
– volume: 60
  start-page: 3642
  year: 2009
  end-page: 3650
  ident: CR62
  article-title: Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.24959
  contributor:
    fullname: Guma
– volume: 30
  start-page: 319
  year: 2009
  end-page: 324
  ident: CR50
  article-title: Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2009.03.012
  contributor:
    fullname: Kovacs
– volume: 15
  start-page: 551
  year: 2016
  ident: CR24
  article-title: Resolution of inflammation: a new therapeutic frontier
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2016.39
  contributor:
    fullname: Gilroy
– volume: 108
  start-page: 5354
  year: 2011
  end-page: 5359
  ident: CR57
  article-title: Microbiota regulates immune defense against respiratory tract influenza A virus infection
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.1019378108
  contributor:
    fullname: Ichinohe
– volume: 50
  start-page: 1602367
  year: 2017
  ident: CR59
  article-title: Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
  publication-title: Eur. Respir. J.
  doi: 10.1183/13993003.02367-2016
  contributor:
    fullname: Lehmann
– volume: 67
  start-page: 40
  year: 2000
  end-page: 45
  ident: CR25
  article-title: Effect of age on human neutrophil function
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/jlb.67.1.40
  contributor:
    fullname: Hörl
– volume: 65
  start-page: 575
  year: 2016
  end-page: 583
  ident: CR56
  article-title: The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-309728
  contributor:
    fullname: de Boer
– volume: 64
  start-page: 2289
  year: 2015
  end-page: 2298
  ident: CR58
  article-title: Cellular senescence in type 2 diabetes: a therapeutic opportunity
  publication-title: Diabetes
  doi: 10.2337/db14-1820
  contributor:
    fullname: Palmer
– volume: 314
  start-page: L6
  year: 2018
  end-page: L16
  ident: CR44
  article-title: IL-17 in the lung: the good, the bad, and the ugly
  publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00344.2017
  contributor:
    fullname: Moore
– volume: 13
  start-page: 690
  year: 2014
  end-page: 698
  ident: CR28
  article-title: Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals
  publication-title: Aging Cell
  doi: 10.1111/acel.12222
  contributor:
    fullname: Hazeldine
– volume: 500
  start-page: 490
  year: 2018
  end-page: 496
  ident: CR34
  article-title: Augmented neutrophil extracellular traps formation promotes atherosclerosis development in socially defeated apoE−/− mice
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2018.04.115
  contributor:
    fullname: Yamamoto
– volume: 294
  start-page: 2712
  year: 2005
  end-page: 2719
  ident: CR3
  article-title: Trends in hospitalizations for pneumonia among persons aged 65 years or older in the United States, 1988-2002
  publication-title: JAMA
  doi: 10.1001/jama.294.21.2712
  contributor:
    fullname: Anderson
– volume: 349
  start-page: aaa4352
  year: 2015
  ident: CR15
  article-title: Neutrophil trails guide influenza-specific CD8(+) T cells in the airways
  publication-title: Science
  doi: 10.1126/science.aaa4352
  contributor:
    fullname: Lim
– volume: 352
  start-page: 463
  year: 2016
  end-page: 466
  ident: CR7
  article-title: Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
  publication-title: Science
  doi: 10.1126/science.aaf3926
  contributor:
    fullname: Pillai
– volume: 4
  start-page: 1798
  year: 2009
  ident: CR47
  article-title: Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2009.191
  contributor:
    fullname: Toussaint
– volume: 15
  start-page: 19571
  year: 2010
  ident: CR2
  article-title: Pandemic Influenza A (H1N1) 2009 and mortality in the United Kingdom: risk factors for death, April 2009 to March 2010
  publication-title: Eur. Surveill.
  contributor:
    fullname: Pebody
– volume: 123
  start-page: 966
  year: 2013
  end-page: 972
  ident: CR46
  article-title: Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI64098
  contributor:
    fullname: Kirkland
– volume: 38
  start-page: 187
  year: 2013
  end-page: 197
  ident: CR66
  article-title: Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.09.020
  contributor:
    fullname: Sathaliyawala
– volume: 6
  start-page: e1000661
  year: 2010
  ident: CR36
  article-title: IL-1β processing in host defense: beyond the inflammasomes
  publication-title: PLoS. Pathog.
  doi: 10.1371/journal.ppat.1000661
  contributor:
    fullname: Netea
– volume: 133
  start-page: 235
  year: 2008
  end-page: 249
  ident: CR23
  article-title: Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
  publication-title: Cell
  doi: 10.1016/j.cell.2008.02.043
  contributor:
    fullname: Imai
– volume: 6
  year: 2016
  ident: CR11
  article-title: Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses
  publication-title: Sci. Rep.
  doi: 10.1038/srep25051
  contributor:
    fullname: Haynes
– volume: 10
  start-page: 112
  year: 2009
  ident: CR12
  article-title: Impaired immune responses in the lungs of aged mice following influenza infection
  publication-title: Respir. Res.
  doi: 10.1186/1465-9921-10-112
  contributor:
    fullname: Ross
– volume: 11
  start-page: S12
  issue: s1
  year: 2006
  end-page: S15
  ident: CR45
  article-title: Biology of alveolar type II cells
  publication-title: Respirology
  doi: 10.1111/j.1440-1843.2006.00800.x
  contributor:
    fullname: Mason
– volume: 10
  start-page: 422
  year: 2011
  end-page: 427
  ident: CR9
  article-title: CD8 T cell responses to influenza virus infection in aged mice
  publication-title: Ageing Res. Rev.
  contributor:
    fullname: Murasko
– volume: 34
  start-page: 1733
  year: 2004
  end-page: 1743
  ident: CR35
  article-title: The survival effect of TNF-α in human neutrophils is mediated via NF-κB-dependent IL-8 release
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200425091
  contributor:
    fullname: Chilvers
– volume: 13
  start-page: 875
  year: 2013
  end-page: 887
  ident: CR5
  article-title: Age-dependent dysregulation of innate immunity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3547
  contributor:
    fullname: Montgomery
– volume: 184
  start-page: 1410
  year: 2010
  end-page: 1418
  ident: CR19
  article-title: Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901709
  contributor:
    fullname: Seki
– volume: 25
  start-page: 231
  year: 1992
  end-page: 243
  ident: CR37
  article-title: Lactate dehydrogenase (LDH) activity of the number of dead cells in the medium of cultured eukaryotic cells as marker
  publication-title: J. Biotechnol.
  doi: 10.1016/0168-1656(92)90158-6
  contributor:
    fullname: Legrand
– ident: CR18
– volume: 79
  start-page: 3966
  year: 2011
  end-page: 3977
  ident: CR61
  article-title: Neutrophils produce interleukin 17A (IL-17A) in a Dectin-1- and IL-23-dependent manner during invasive fungal infection
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.05493-11
  contributor:
    fullname: Werner
– volume: 73
  start-page: 546
  year: 2018
  end-page: 556
  ident: CR20
  article-title: Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection
  publication-title: Thorax
  doi: 10.1136/thoraxjnl-2017-210010
  contributor:
    fullname: Peiró
– volume: 104
  start-page: 565
  year: 2004
  end-page: 571
  ident: CR51
  article-title: Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis
  publication-title: Blood
  doi: 10.1182/blood-2003-10-3638
  contributor:
    fullname: Suratt
– volume: 183
  start-page: 5301
  year: 2009
  end-page: 5310
  ident: CR43
  article-title: Critical role of IL-17RA in immunopathology of influenza infection
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0900995
  contributor:
    fullname: Crowe
– volume: 188
  start-page: 2815
  year: 2012
  end-page: 2824
  ident: CR31
  article-title: Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1103051
  contributor:
    fullname: Harrod
– volume: 20
  start-page: 369
  year: 2007
  end-page: 378
  ident: CR40
  article-title: CXCR2 is required for neutrophil recruitment to the lung during influenza virus infection, but is not essential for viral clearance
  publication-title: Viral Immunol.
  doi: 10.1089/vim.2006.0101
  contributor:
    fullname: Sarawar
– volume: 154
  start-page: 5411
  year: 1995
  end-page: 5417
  ident: CR64
  article-title: TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation
  publication-title: J. Immunol.
  contributor:
    fullname: Kunkel
– volume: 0
  start-page: e12949
  year: 2018
  ident: CR41
  article-title: the master regulator of neutrophil trafficking in homoeostasis and disease
  publication-title: Eur. J. Clin. Invest.
  doi: 10.1111/eci.12949
  contributor:
    fullname: Rankin
– volume: 9
  start-page: 181
  year: 2014
  end-page: 218
  ident: CR60
  article-title: The multifaceted functions of neutrophils
  publication-title: Annu. Rev. Pathol. Mech. Dis.
  doi: 10.1146/annurev-pathol-020712-164023
  contributor:
    fullname: Lowell
– ident: CR6
– volume: 125
  start-page: 281
  year: 2008
  end-page: 288
  ident: CR39
  article-title: Neutrophil mobilization and clearance in the bone marrow
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2008.02950.x
  contributor:
    fullname: Rankin
– volume: 45
  start-page: 1568
  year: 2007
  end-page: 1575
  ident: CR48
  article-title: Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/523584
  contributor:
    fullname: McGeer
– volume: 14
  start-page: 81
  year: 2014
  end-page: 93
  ident: CR49
  article-title: Alveolar macrophages: plasticity in a tissue-specific context
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3600
  contributor:
    fullname: Bell
– volume: 488
  start-page: 178
  year: 2012
  ident: CR54
  article-title: Gut microbiota composition correlates with diet and health in the elderly
  publication-title: Nature
  doi: 10.1038/nature11319
  contributor:
    fullname: Claesson
– volume: 9
  start-page: 57
  year: 2008
  ident: CR16
  article-title: The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice
  publication-title: Respir. Res.
  doi: 10.1186/1465-9921-9-57
  contributor:
    fullname: Reading
– volume: 154
  start-page: 197
  year: 2013
  end-page: 212
  ident: CR21
  article-title: A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection
  publication-title: Cell
  doi: 10.1016/j.cell.2013.06.013
  contributor:
    fullname: Germain Ronald
– volume: 7
  start-page: 502
  year: 2016
  end-page: 502
  ident: CR32
  article-title: Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2016.00502
  contributor:
    fullname: Takizawa
– ident: CR69
– volume: 289
  start-page: 179
  year: 2003
  end-page: 186
  ident: CR1
  article-title: Mortality associated with influenza and respiratory syncytial virus in the United States
  publication-title: JAMA.
  doi: 10.1001/jama.289.2.179
  contributor:
    fullname: Thompson
– volume: 21
  start-page: 21
  year: 2017
  end-page: 28
  ident: CR68
  article-title: Cellular senescence: a translational perspective
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2017.04.013
  contributor:
    fullname: Tchkonia
– volume: 2
  start-page: 8
  year: 2013
  end-page: 8
  ident: CR53
  article-title: Understanding how we age: insights into inflammaging
  publication-title: Longev. Health
  doi: 10.1186/2046-2395-2-8
  contributor:
    fullname: Roberts
– volume: 132
  start-page: 503
  year: 2011
  end-page: 510
  ident: CR8
  article-title: Natural killer cell function is altered during the primary response of aged mice to influenza infection
  publication-title: Mech. Ageing Dev.
  doi: 10.1016/j.mad.2011.08.005
  contributor:
    fullname: Beli
– volume: 3
  start-page: 217
  year: 2004
  end-page: 226
  ident: CR26
  article-title: Signal transduction and functional changes in neutrophils with aging
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9728.2004.00110.x
  contributor:
    fullname: Fulop
– volume: 31
  start-page: 318
  year: 2010
  end-page: 324
  ident: CR13
  article-title: Neutrophil kinetics in health and disease
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2010.05.006
  contributor:
    fullname: Summers
– volume: 20
  start-page: 596
  year: 2016
  end-page: 605
  ident: CR42
  article-title: IL-17 receptor signaling in the lung epithelium is required for mucosal chemokine gradients and pulmonary host defense against
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.10.003
  contributor:
    fullname: Chen
– volume: 199
  start-page: 1060
  year: 2017
  end-page: 1068
  ident: CR30
  article-title: Aging impairs alveolar macrophage phagocytosis and increases influenza-induced mortality in mice
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1700397
  contributor:
    fullname: Wong
– volume: 18
  start-page: 134
  year: 2017
  ident: CR22
  article-title: Neutrophil extracellular traps in immunity and disease
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2017.105
  contributor:
    fullname: Papayannopoulos
– volume: 123
  start-page: 239
  year: 2014
  end-page: 248
  ident: CR27
  article-title: Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
  publication-title: Blood
  doi: 10.1182/blood-2013-08-519520
  contributor:
    fullname: Sapey
– volume: 5
  start-page: 508
  year: 2014
  end-page: 508
  ident: CR63
  article-title: Neutrophil-derived cytokines: facts beyond expression
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2014.00508
  contributor:
    fullname: Cassatella
– volume: 132
  start-page: 163
  year: 2011
  end-page: 170
  ident: CR10
  article-title: Expansion of regulatory T cells in aged mice following influenza infection
  publication-title: Mech. Ageing Dev.
  doi: 10.1016/j.mad.2011.03.001
  contributor:
    fullname: Murasko
– volume: 16
  start-page: 228
  year: 2010
  ident: CR55
  article-title: Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
  publication-title: Nat. Med.
  doi: 10.1038/nm.2087
  contributor:
    fullname: Clarke
– volume: 21
  start-page: 677
  year: 2015
  end-page: 687
  ident: CR67
  article-title: Inflammasomes: mechanism of action, role in disease, and therapeutics
  publication-title: Nat. Med.
  doi: 10.1038/nm.3893
  contributor:
    fullname: Ting
– volume: 183
  start-page: 7441
  year: 2009
  end-page: 7450
  ident: CR17
  article-title: Neutrophils ameliorate lung injury and the development of severe disease during influenza infection
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0902497
  contributor:
    fullname: Tate
– volume: 178
  start-page: 8148
  year: 2007
  end-page: 8157
  ident: CR52
  article-title: Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.178.12.8148
  contributor:
    fullname: Petty
– volume: 123
  start-page: 239
  year: 2014
  ident: 10.1038/s41385-018-0115-3_bib27
  article-title: Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
  publication-title: Blood
  doi: 10.1182/blood-2013-08-519520
  contributor:
    fullname: Sapey
– volume: 314
  start-page: L6
  year: 2018
  ident: 10.1038/s41385-018-0115-3_bib44
  article-title: IL-17 in the lung: the good, the bad, and the ugly
  publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00344.2017
  contributor:
    fullname: Gurczynski
– volume: 50
  start-page: 1602367
  year: 2017
  ident: 10.1038/s41385-018-0115-3_bib59
  article-title: Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
  publication-title: Eur. Respir. J.
  doi: 10.1183/13993003.02367-2016
  contributor:
    fullname: Lehmann
– volume: 13
  start-page: 875
  year: 2013
  ident: 10.1038/s41385-018-0115-3_bib5
  article-title: Age-dependent dysregulation of innate immunity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3547
  contributor:
    fullname: Shaw
– volume: 67
  start-page: 40
  year: 2000
  ident: 10.1038/s41385-018-0115-3_bib25
  article-title: Effect of age on human neutrophil function
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/jlb.67.1.40
  contributor:
    fullname: Wenisch
– volume: 20
  start-page: 369
  year: 2007
  ident: 10.1038/s41385-018-0115-3_bib40
  article-title: CXCR2 is required for neutrophil recruitment to the lung during influenza virus infection, but is not essential for viral clearance
  publication-title: Viral Immunol.
  doi: 10.1089/vim.2006.0101
  contributor:
    fullname: Wareing
– volume: 14
  start-page: 81
  year: 2014
  ident: 10.1038/s41385-018-0115-3_bib49
  article-title: Alveolar macrophages: plasticity in a tissue-specific context
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3600
  contributor:
    fullname: Hussell
– volume: 34
  start-page: 1733
  year: 2004
  ident: 10.1038/s41385-018-0115-3_bib35
  article-title: The survival effect of TNF-α in human neutrophils is mediated via NF-κB-dependent IL-8 release
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200425091
  contributor:
    fullname: Cowburn
– volume: 4
  start-page: 1798
  year: 2009
  ident: 10.1038/s41385-018-0115-3_bib47
  article-title: Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2009.191
  contributor:
    fullname: Debacq-Chainiaux
– volume: 6
  year: 2016
  ident: 10.1038/s41385-018-0115-3_bib11
  article-title: Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses
  publication-title: Sci. Rep.
  doi: 10.1038/srep25051
  contributor:
    fullname: Lefebvre
– ident: 10.1038/s41385-018-0115-3_bib69
– volume: 21
  start-page: 21
  year: 2017
  ident: 10.1038/s41385-018-0115-3_bib68
  article-title: Cellular senescence: a translational perspective
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2017.04.013
  contributor:
    fullname: Kirkland
– volume: 79
  start-page: 3966
  year: 2011
  ident: 10.1038/s41385-018-0115-3_bib61
  article-title: Neutrophils produce interleukin 17A (IL-17A) in a Dectin-1- and IL-23-dependent manner during invasive fungal infection
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.05493-11
  contributor:
    fullname: Werner
– volume: 294
  start-page: 2712
  year: 2005
  ident: 10.1038/s41385-018-0115-3_bib3
  article-title: Trends in hospitalizations for pneumonia among persons aged 65 years or older in the United States, 1988-2002
  publication-title: JAMA
  doi: 10.1001/jama.294.21.2712
  contributor:
    fullname: Fry
– volume: 65
  start-page: 575
  year: 2016
  ident: 10.1038/s41385-018-0115-3_bib56
  article-title: The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-309728
  contributor:
    fullname: Schuijt
– volume: 116
  start-page: 1218
  year: 2006
  ident: 10.1038/s41385-018-0115-3_bib65
  article-title: The IL-23/IL-17 axis in inflammation
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI28508
  contributor:
    fullname: Iwakura
– volume: 25
  start-page: 231
  year: 1992
  ident: 10.1038/s41385-018-0115-3_bib37
  article-title: Lactate dehydrogenase (LDH) activity of the number of dead cells in the medium of cultured eukaryotic cells as marker
  publication-title: J. Biotechnol.
  doi: 10.1016/0168-1656(92)90158-6
  contributor:
    fullname: Legrand
– volume: 38
  start-page: 187
  year: 2013
  ident: 10.1038/s41385-018-0115-3_bib66
  article-title: Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.09.020
  contributor:
    fullname: Sathaliyawala
– volume: 184
  start-page: 1410
  year: 2010
  ident: 10.1038/s41385-018-0115-3_bib19
  article-title: Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901709
  contributor:
    fullname: Seki
– volume: 6
  start-page: e1000661
  year: 2010
  ident: 10.1038/s41385-018-0115-3_bib36
  article-title: IL-1β processing in host defense: beyond the inflammasomes
  publication-title: PLoS. Pathog.
  doi: 10.1371/journal.ppat.1000661
  contributor:
    fullname: Netea
– volume: 15
  start-page: 551
  year: 2016
  ident: 10.1038/s41385-018-0115-3_bib24
  article-title: Resolution of inflammation: a new therapeutic frontier
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2016.39
  contributor:
    fullname: Fullerton
– volume: 0
  start-page: e12949
  year: 2018
  ident: 10.1038/s41385-018-0115-3_bib41
  article-title: the master regulator of neutrophil trafficking in homoeostasis and disease
  publication-title: Eur. J. Clin. Invest.
  doi: 10.1111/eci.12949
  contributor:
    fullname: De Filippo.
– volume: 132
  start-page: 163
  year: 2011
  ident: 10.1038/s41385-018-0115-3_bib10
  article-title: Expansion of regulatory T cells in aged mice following influenza infection
  publication-title: Mech. Ageing Dev.
  doi: 10.1016/j.mad.2011.03.001
  contributor:
    fullname: Williams-Bey
– volume: 20
  start-page: 596
  year: 2016
  ident: 10.1038/s41385-018-0115-3_bib42
  article-title: IL-17 receptor signaling in the lung epithelium is required for mucosal chemokine gradients and pulmonary host defense against K. pneumoniae
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.10.003
  contributor:
    fullname: Chen
– ident: 10.1038/s41385-018-0115-3_bib18
  doi: 10.3389/fimmu.2017.00550
– volume: 500
  start-page: 490
  year: 2018
  ident: 10.1038/s41385-018-0115-3_bib34
  article-title: Augmented neutrophil extracellular traps formation promotes atherosclerosis development in socially defeated apoE−/− mice
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2018.04.115
  contributor:
    fullname: Yamamoto
– volume: 488
  start-page: 178
  year: 2012
  ident: 10.1038/s41385-018-0115-3_bib54
  article-title: Gut microbiota composition correlates with diet and health in the elderly
  publication-title: Nature
  doi: 10.1038/nature11319
  contributor:
    fullname: Claesson
– volume: 73
  start-page: 546
  year: 2018
  ident: 10.1038/s41385-018-0115-3_bib20
  article-title: Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection
  publication-title: Thorax
  doi: 10.1136/thoraxjnl-2017-210010
  contributor:
    fullname: Peiró
– volume: 133
  start-page: 235
  year: 2008
  ident: 10.1038/s41385-018-0115-3_bib23
  article-title: Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
  publication-title: Cell
  doi: 10.1016/j.cell.2008.02.043
  contributor:
    fullname: Imai
– volume: 31
  start-page: 318
  year: 2010
  ident: 10.1038/s41385-018-0115-3_bib13
  article-title: Neutrophil kinetics in health and disease
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2010.05.006
  contributor:
    fullname: Summers
– volume: 132
  start-page: 503
  year: 2011
  ident: 10.1038/s41385-018-0115-3_bib8
  article-title: Natural killer cell function is altered during the primary response of aged mice to influenza infection
  publication-title: Mech. Ageing Dev.
  doi: 10.1016/j.mad.2011.08.005
  contributor:
    fullname: Beli
– volume: 349
  start-page: aaa4352
  year: 2015
  ident: 10.1038/s41385-018-0115-3_bib15
  article-title: Neutrophil trails guide influenza-specific CD8(+) T cells in the airways
  publication-title: Science
  doi: 10.1126/science.aaa4352
  contributor:
    fullname: Lim
– volume: 188
  start-page: 2815
  year: 2012
  ident: 10.1038/s41385-018-0115-3_bib31
  article-title: Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1103051
  contributor:
    fullname: Stout-Delgado
– volume: 352
  start-page: 463
  year: 2016
  ident: 10.1038/s41385-018-0115-3_bib7
  article-title: Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
  publication-title: Science
  doi: 10.1126/science.aaf3926
  contributor:
    fullname: Pillai
– volume: 10
  start-page: 112
  year: 2009
  ident: 10.1038/s41385-018-0115-3_bib12
  article-title: Impaired immune responses in the lungs of aged mice following influenza infection
  publication-title: Respir. Res.
  doi: 10.1186/1465-9921-10-112
  contributor:
    fullname: Toapanta
– volume: 183
  start-page: 5301
  year: 2009
  ident: 10.1038/s41385-018-0115-3_bib43
  article-title: Critical role of IL-17RA in immunopathology of influenza infection
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0900995
  contributor:
    fullname: Crowe
– volume: 21
  start-page: 455
  year: 2017
  ident: 10.1038/s41385-018-0115-3_bib29
  article-title: Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2017.03.002
  contributor:
    fullname: Thevaranjan
– volume: 45
  start-page: 1568
  year: 2007
  ident: 10.1038/s41385-018-0115-3_bib48
  article-title: Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/523584
  contributor:
    fullname: McGeer
– volume: 21
  start-page: 677
  year: 2015
  ident: 10.1038/s41385-018-0115-3_bib67
  article-title: Inflammasomes: mechanism of action, role in disease, and therapeutics
  publication-title: Nat. Med.
  doi: 10.1038/nm.3893
  contributor:
    fullname: Guo
– volume: 64
  start-page: 2289
  year: 2015
  ident: 10.1038/s41385-018-0115-3_bib58
  article-title: Cellular senescence in type 2 diabetes: a therapeutic opportunity
  publication-title: Diabetes
  doi: 10.2337/db14-1820
  contributor:
    fullname: Palmer
– volume: 60
  start-page: 3642
  year: 2009
  ident: 10.1038/s41385-018-0115-3_bib62
  article-title: Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.24959
  contributor:
    fullname: Guma
– volume: 11
  start-page: S12
  issue: s1
  year: 2006
  ident: 10.1038/s41385-018-0115-3_bib45
  article-title: Biology of alveolar type II cells
  publication-title: Respirology
  doi: 10.1111/j.1440-1843.2006.00800.x
  contributor:
    fullname: Mason
– volume: 104
  start-page: 565
  year: 2004
  ident: 10.1038/s41385-018-0115-3_bib51
  article-title: Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis
  publication-title: Blood
  doi: 10.1182/blood-2003-10-3638
  contributor:
    fullname: Suratt
– volume: 2
  start-page: 8
  year: 2013
  ident: 10.1038/s41385-018-0115-3_bib53
  article-title: Understanding how we age: insights into inflammaging
  publication-title: Longev. Health
  doi: 10.1186/2046-2395-2-8
  contributor:
    fullname: Baylis
– volume: 199
  start-page: 1060
  year: 2017
  ident: 10.1038/s41385-018-0115-3_bib30
  article-title: Aging impairs alveolar macrophage phagocytosis and increases influenza-induced mortality in mice
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1700397
  contributor:
    fullname: Wong
– volume: 7
  start-page: 502
  year: 2016
  ident: 10.1038/s41385-018-0115-3_bib32
  article-title: Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2016.00502
  contributor:
    fullname: Kovtonyuk
– ident: 10.1038/s41385-018-0115-3_bib6
  doi: 10.3389/fimmu.2016.00041
– volume: 187
  start-page: 1040
  year: 2018
  ident: 10.1038/s41385-018-0115-3_bib4
  article-title: Systematic assessment of multiple routine and near real-time indicators to classify the severity of influenza seasons and pandemics in the United States, 2003–2004 through 2015–2016
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwx334
  contributor:
    fullname: Biggerstaff
– volume: 330
  start-page: 362
  year: 2010
  ident: 10.1038/s41385-018-0115-3_bib14
  article-title: Intravascular danger signals guide neutrophils to sites of sterile inflammation
  publication-title: Science
  doi: 10.1126/science.1195491
  contributor:
    fullname: McDonald
– volume: 154
  start-page: 197
  year: 2013
  ident: 10.1038/s41385-018-0115-3_bib21
  article-title: A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection
  publication-title: Cell
  doi: 10.1016/j.cell.2013.06.013
  contributor:
    fullname: Brandes
– volume: 154
  start-page: 5411
  year: 1995
  ident: 10.1038/s41385-018-0115-3_bib64
  article-title: TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.154.10.5411
  contributor:
    fullname: Lukacs
– volume: 10
  start-page: 422
  year: 2011
  ident: 10.1038/s41385-018-0115-3_bib9
  article-title: CD8 T cell responses to influenza virus infection in aged mice
  publication-title: Ageing Res. Rev.
  contributor:
    fullname: Jiang
– volume: 125
  start-page: 281
  year: 2008
  ident: 10.1038/s41385-018-0115-3_bib39
  article-title: Neutrophil mobilization and clearance in the bone marrow
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2008.02950.x
  contributor:
    fullname: Furze
– volume: 1250
  start-page: 349
  year: 2015
  ident: 10.1038/s41385-018-0115-3_bib38
  article-title: Measurement of apoptotic and necrotic cell death in primary hepatocyte cultures
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-2074-7_27
  contributor:
    fullname: Maes
– volume: 16
  start-page: 228
  year: 2010
  ident: 10.1038/s41385-018-0115-3_bib55
  article-title: Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
  publication-title: Nat. Med.
  doi: 10.1038/nm.2087
  contributor:
    fullname: Clarke
– volume: 5
  start-page: 508
  year: 2014
  ident: 10.1038/s41385-018-0115-3_bib63
  article-title: Neutrophil-derived cytokines: facts beyond expression
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2014.00508
  contributor:
    fullname: Tecchio
– volume: 108
  start-page: 5354
  year: 2011
  ident: 10.1038/s41385-018-0115-3_bib57
  article-title: Microbiota regulates immune defense against respiratory tract influenza A virus infection
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.1019378108
  contributor:
    fullname: Ichinohe
– volume: 30
  start-page: 319
  year: 2009
  ident: 10.1038/s41385-018-0115-3_bib50
  article-title: Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2009.03.012
  contributor:
    fullname: Kovacs
– volume: 178
  start-page: 8148
  year: 2007
  ident: 10.1038/s41385-018-0115-3_bib52
  article-title: Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.178.12.8148
  contributor:
    fullname: Petty
– volume: 183
  start-page: 7441
  year: 2009
  ident: 10.1038/s41385-018-0115-3_bib17
  article-title: Neutrophils ameliorate lung injury and the development of severe disease during influenza infection
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0902497
  contributor:
    fullname: Tate
– volume: 123
  start-page: 966
  year: 2013
  ident: 10.1038/s41385-018-0115-3_bib46
  article-title: Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI64098
  contributor:
    fullname: Tchkonia
– volume: 9
  start-page: 181
  year: 2014
  ident: 10.1038/s41385-018-0115-3_bib60
  article-title: The multifaceted functions of neutrophils
  publication-title: Annu. Rev. Pathol. Mech. Dis.
  doi: 10.1146/annurev-pathol-020712-164023
  contributor:
    fullname: Mayadas
– volume: 9
  start-page: 57
  year: 2008
  ident: 10.1038/s41385-018-0115-3_bib16
  article-title: The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice
  publication-title: Respir. Res.
  doi: 10.1186/1465-9921-9-57
  contributor:
    fullname: Tate
– volume: 15
  start-page: 19571
  year: 2010
  ident: 10.1038/s41385-018-0115-3_bib2
  article-title: Pandemic Influenza A (H1N1) 2009 and mortality in the United Kingdom: risk factors for death, April 2009 to March 2010
  publication-title: Eur. Surveill.
  doi: 10.2807/ese.15.20.19571-en
  contributor:
    fullname: Pebody
– volume: 13
  start-page: 690
  year: 2014
  ident: 10.1038/s41385-018-0115-3_bib28
  article-title: Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals
  publication-title: Aging Cell
  doi: 10.1111/acel.12222
  contributor:
    fullname: Hazeldine
– volume: 3
  start-page: 217
  year: 2004
  ident: 10.1038/s41385-018-0115-3_bib26
  article-title: Signal transduction and functional changes in neutrophils with aging
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9728.2004.00110.x
  contributor:
    fullname: Fulop
– volume: 179
  start-page: 199
  year: 2011
  ident: 10.1038/s41385-018-0115-3_bib33
  article-title: Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2011.03.013
  contributor:
    fullname: Narasaraju
– volume: 289
  start-page: 179
  year: 2003
  ident: 10.1038/s41385-018-0115-3_bib1
  article-title: Mortality associated with influenza and respiratory syncytial virus in the United States
  publication-title: JAMA.
  doi: 10.1001/jama.289.2.179
  contributor:
    fullname: Thompson
– volume: 18
  start-page: 134
  year: 2017
  ident: 10.1038/s41385-018-0115-3_bib22
  article-title: Neutrophil extracellular traps in immunity and disease
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2017.105
  contributor:
    fullname: Papayannopoulos
SSID ssj0060053
Score 2.5464375
Snippet Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection;...
SourceID pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 545
SubjectTerms Aging
Aging - physiology
Allergology
Alveoli
Animals
Antibodies
Biomedical and Life Sciences
Biomedicine
Cell Count
Cellular Senescence
Chemokine CXCL1 - metabolism
Chemokine CXCL2 - metabolism
Chemokines
Chemotaxis
Epithelial cells
Epithelial Cells - physiology
Epithelial Cells - virology
Gastroenterology
Geriatrics
Humans
Immune clearance
Immune response
Immunology
Infections
Influenza
Influenza, Human - immunology
Influenza, Human - mortality
Leukocytes (neutrophilic)
Lung - pathology
Mice
Mice, Inbred C57BL
Mortality
Neutrophils
Neutrophils - immunology
Neutrophils - virology
Senescence
Survival Analysis
Viral infections
Title Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality
URI https://link.springer.com/article/10.1038/s41385-018-0115-3
https://www.ncbi.nlm.nih.gov/pubmed/30617300
https://www.proquest.com/docview/2179727898
https://search.proquest.com/docview/2165059271
https://pubmed.ncbi.nlm.nih.gov/PMC6375784
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS-QwEB9ORbiXw8-7nh_kwCcl2HbapH0SlRURTg5R2LeSpllcWLt721248693ph8rq-hrM6XpTDL5Jb_JDMCRjYpE2diXgU2NjDA0MjEYyoGlXQ-NH2fqvAW_b9X1Q3TTj_vtgVvVhlV2PrF21MXY8hn5KUHnVPO1zeRs8ldy1ShmV9sSGiuwFgYR07RrF73bP3edL1Y8xhpemdnKIO14TUxOK3LfCQeucTBXEEtcXpnewc33UZNvqNN6RbragG8tlBTnje034Ysrt2C9KS75fxts7x9fASBvJko3n03Hk8fhSIw4SKgSw1IQ8hMjmuqCr5FNCYrWT8i9SNOazBUkx6iycvzCsKln8mzEU43ZCb_vwMNV7_7yWrYlFaSNtD-TOQ6UxrAwOdevM46muLNkLY3Wz0nBThltbOjCtDAkqlRsLaKL0zBRJo1i3IXVcly6HyDQ2sJhYOtlPoninPbSJDiwaeEKcgUeHHfqzCZN5oysZrwxyRrdZ6T7jHWfoQf7ncKzdhJV2avJPfi1aKbhz5yGKd14zjIEMal7OvDge2OfxdeQ4Rn6vgd6yXILAU6tvdxSDh_rFNsKOc9_5MFJZ-PXbn34Ez8__4k9-EpoK20C2PZhdTaduwNCNLP8EFZ0Xx-2g_cFAp31tw
link.rule.ids 230,315,786,790,891,12083,21416,27955,27956,31752,31753,33777,33778,43343,43838,74100,74657
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDLdgCMEL4pvCBkHiCRStrdO0fUJo2nTAtqdNurcoTXPaSbfecb2TNv567LS96Zi218ZRE9txfokdG-CLU3WhXRbLxJVWKkytLCymcuLo1EP6423IW3Byqkfn6tc4G_cXbm0fVjnYxGCo67njO_J9gs5lzs82i--LP5KrRrF3tS-h8RAeKUTFep6PNwcuzRrWeZXZV5mUg1cTi_2WjHfBYWscypVkErf3pVtg83bM5H-O07AfHT2HZz2QFD86yb-AB755CY-70pLXr8AdXvEDALJlovHr1XK-uJjOxIxDhFoxbQThPjGjhS74EdmSgGj4QsZF2l5gviY6xpSt5w7TrprJXysuA2In9P4azo8Ozw5Gsi-oIJ3K45WscKJzTGtbcfU662mBe0eyytHFFbHXa5tbl_q0rC2Rap05h-izMi20LVWGb2CnmTf-HQh0rvaYuLDJFyqr6CRNhBNX1r4mQxDB14GdZtHlzTDB342F6XhviPeGeW8wgt2B4aZfQq25EXgEnzfNpPzs0bCNn6-ZhgAmDS9PInjbyWfzN2RwhnEcQb4luQ0BJ9bebmmmFyHBtkbO8q8i-DbI-GZYd07i_f2T-ARPRmcnx-b45-nvD_CUcFfZhbLtws5qufZ7hG1W1cegwP8AwNL2Vw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED-NTSBeEIyvwMaMxBPIapJLnOQJoW3VBmPigUl9sxzH1SqVtGtaaeyv585JOpVpe40vin1f_jl3vgP4ZJMqVzYNZWQLIxOMjcwNxnJs6dRD-uOMr1vw81ydXCTfR-moy39qurTK3id6R13NLP8jHxB0LjK-tpkPxl1axK-j4df5leQOUhxp7dppPIId2iVDbuOQjdaHL8Xa1kaYOW4ZFX2EE_NBQ4485xQ2TuuKUombe9Qd4Hk3f_K_IKrfm4bP4VkHKsW3VgtewJard-Fx22by70uwx9d8GYD8mqjdarmYzS8nUzHldKFGTGpBGFBMyegFXyhbECj1T8jRSNMJz1VEx_iycfzCpO1scmPEH4_eCcm_govh8e_DE9k1V5A2ycKlLHGsMowrU3InO-PI2J0luWVow5JY7ZTJjI1dXFSGSJVKrUV0aRHnyhRJiq9hu57V7i0ItLZyGFm_4edJWtKpmgjHtqhcRU4hgM89O_W8raGhfewbc93yXhPvNfNeYwB7PcN1Z06NvhV-AB_Xw2QIHN0wtZutmIbAJk0viwJ408pn_TVkoIZhGEC2Ibk1ARfZ3hypJ5e-2LZCrvifBPCll_HttO5dxLuHF3EAT0h39dnp-Y_38JQgWNFmte3B9nKxcvsEc5blB6-__wA4ffqD
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Excessive+neutrophil+levels+in+the+lung+underlie+the+age-associated+increase+in+influenza+mortality&rft.jtitle=Mucosal+immunology&rft.au=Kulkarni%2C+Upasana&rft.au=Zemans%2C+Rachel+L&rft.au=Smith%2C+Candice+A&rft.au=Wood%2C+Sherri+C&rft.date=2019-03-01&rft.eissn=1935-3456&rft.volume=12&rft.issue=2&rft.spage=545&rft_id=info:doi/10.1038%2Fs41385-018-0115-3&rft_id=info%3Apmid%2F30617300&rft.externalDocID=30617300
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1933-0219&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1933-0219&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1933-0219&client=summon