Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma

• Published in: British journal of cancer Vol. 120; no. 1; pp. 54 - 56
• Main Authors: Wang, Sumei, O’Rourke, Donald M., Chawla, Sanjeev, Verma, Gaurav, Nasrallah, MacLean P., Morrissette, Jennifer J. D., Plesa, Gabriela, June, Carl H., Brem, Steven, Maloney, Eileen, Desai, Arati, Wolf, Ronald L., Poptani, Harish, Mohan, Suyash
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.01.2019; Nature Publishing Group
• Subjects: 692/4028; 692/4028/67/2321; Antigens; Biomedical and Life Sciences; Biomedicine; Brain cancer; Brief Communication; Cancer Research; Cell Line, Tumor; Chimeric antigen receptors; Drug Resistance; Epidemiology; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - immunology; Female; Glioblastoma; Glioblastoma - diagnostic imaging; Glioblastoma - immunology; Glioblastoma - pathology; Glioblastoma - therapy; Humans; Immunotherapy, Adoptive; Lymphocytes T; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Medicine; Neoplasm Recurrence, Local - diagnostic imaging; Neoplasm Recurrence, Local - immunology; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; NMR; Nuclear magnetic resonance; Oncology; Patients; Receptors, Chimeric Antigen - immunology; Receptors, Chimeric Antigen - therapeutic use; Surgery

EGFRvIII targeted chimeric antigen receptor T (CAR-T) cell therapy has recently been reported for treating glioblastomas (GBMs); however, physiology-based MRI parameters have not been evaluated in this setting. Ten patients underwent multiparametric MRI at baseline, 1, 2 and 3 months after CAR-T the...