Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs

• Published in: Molecular psychiatry Vol. 24; no. 4; pp. 501 - 522
• Main Authors: Niculescu, A. B., Le-Niculescu, H., Levey, D. F., Roseberry, K., Soe, K. C., Rogers, J., Khan, F., Jones, T., Judd, S., McCormick, M. A., Wessel, A. R., Williams, A., Kurian, S. M., White, F. A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2019; Nature Publishing Group
• Subjects: 38/39; 631/208; 692/53/2421; Adult; Aged; Behavioral Sciences; Biological Psychology; Biomarkers; Biomarkers - blood; Biomarkers, Pharmacological - blood; Computational Biology - methods; Contractile Proteins - genetics; Contractile Proteins - metabolism; Drug development; Drug Repositioning - methods; Female; Gene expression; Gene Expression - genetics; Gene Expression Profiling - methods; Genomics - methods; Humans; Immediate Communication; Male; Medicine; Medicine & Public Health; Middle Aged; Neurosciences; Opioids; Pain; Pain - drug therapy; Pain - genetics; Pain perception; Pharmacotherapy; Post traumatic stress disorder; Precision medicine; Precision Medicine - methods; Psychiatry; Pyridoxine; Transcriptome - genetics; Vitamin B12; Vitamin B6

We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk group for co-morbid pain disorders and increa...