Mismatch negativity (MMN) to spatial deviants and behavioral spatial discrimination ability in the etiology of auditory verbal hallucinations and thought disorder in schizophrenia

• Published in: Schizophrenia research Vol. 191; pp. 140 - 147
• Main Authors: Perrin, Megan A., Kantrowitz, Joshua T., Silipo, Gail, Dias, Elisa, Jabado, Omar, Javitt, Daniel C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2018
• Subjects: Acoustic Stimulation; Adult; Analysis of Variance; Auditory cortex; Auditory Cortex - physiopathology; Auditory Perception; Auditory processing; Brain Mapping; Contingent Negative Variation - physiology; Electroencephalography; Evoked Potentials, Auditory - physiology; Female; Hallucinations - etiology; Humans; Male; Middle Aged; Mismatch negativity; Psychiatry; Schizophrenia - complications; Spatial localization; Spatial localization; Mismatch negativity; Auditory processing; Auditory cortex
• DOI: 10.1016/j.schres.2017.05.012
• ISSN: 0920-9964; 1573-2509

Persistent auditory verbal hallucinations (AVH) in schizophrenia are increasingly tied to dysfunction at the level of auditory cortex. AVH may reflect in part misattribution of internally generated thoughts to external spatial locations. Here, we investigated the association between persistent AVH and spatial localization abilities assessed both behaviorally and by mismatch negativity (MMN) to location deviants. Spatial- and tonal- discrimination abilities were assessed in patients (n=20) and controls (n=20) using free-field tones. MMN was assessed to spatial-location-, pitch- and duration-deviants. AVH and thought disorder were assessed using clinical evaluation. As predicted, patients showed significant reductions in behavioral spatial-discrimination (p<0.0001) and tone-matching (p<0.001) ability, along with impaired MMN generation to location (p<0.03) and pitch (p<0.05) deviants. Hallucinating (AVH+) and non-hallucinating (AVH−) subjects showed similar deficits in location MMN to left-hemifield stimuli (p<0.0001 vs. control). By contrast, AVH− patients differed significantly from controls (p=0.009) and AVH+ patients (p=0.018) for MMN to right-lateral hemifield (left auditory cortex) stimuli, whereas AVH+ patients showed paradoxically preserved MMN generation (p=0.99 vs. controls). Severity of thought disorder correlated with impaired spatial discrimination, especially to right-hemifield stimuli (p=0.013), but did not correlate significantly with MMN or tone matching deficits. These findings demonstrate a significant relationship between auditory cortical spatial localization abilities and AVH susceptibility, with relatively preserved function of left vs. right auditory cortex predisposing to more severe AVH, and support models that attribute persistent AVH to impaired source-monitoring. The findings suggest new approaches for therapeutic intervention for both AVH and thought disorder in schizophrenia.