The role of B cells in atherosclerosis

• Published in: Nature reviews cardiology Vol. 16; no. 3; pp. 180 - 196
• Main Authors: Sage, Andrew P, Tsiantoulas, Dimitrios, Binder, Christoph J, Mallat, Ziad
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2019
• Subjects: Animals; Atherosclerosis; Atherosclerosis - immunology; Atherosclerosis - metabolism; Atherosclerosis - pathology; Atherosclerosis - therapy; Autoimmunity; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; B-Lymphocyte Subsets - pathology; Cytokines; Dyslipidemias - immunology; Dyslipidemias - metabolism; Dyslipidemias - therapy; Humans; Immunoglobulins; Immunotherapy; Phenotype; Plaque, Atherosclerotic; Receptors, Antigen, B-Cell - immunology; Receptors, Antigen, B-Cell - metabolism; Signal Transduction

The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis is most prominent and accounts for the majority of deaths globally. Antibody-producing B cells perform a unique role i...