Cerebral hemodynamic characteristics of acute mountain sickness upon acute high-altitude exposure at 3,700 m in young Chinese men

Purpose We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS). Methods Transcranial Doppler (TCD) sonography examinations were performed between 18 and 24 h after arrival at 3,700 m via plane from 500 m ( n  = 454). A subgroup of 151 subjects received TCD...

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Published inEuropean journal of applied physiology Vol. 114; no. 10; pp. 2193 - 2200
Main Authors Bian, Shi-Zhu, Jin, Jun, Li, Qian-Ning, Qin, Jun, Zhang, Ji-Hang, Yu, Shi-Yong, Chen, Jian-Fei, Tang, Cai-Fa, Huang, Lan
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2014
Springer Nature B.V
Subjects
Adolescent
Adult
Age Factors
Altitude
Altitude Sickness - physiopathology
Asymmetry
Biomedical and Life Sciences
Biomedicine
Cardiology
Case-Control Studies
Cerebrovascular Circulation
Headaches
Hemodynamics
Human Physiology
Humans
Hypoxia
Male
Middle Aged
Occupational Medicine/Industrial Medicine
Original
Original Article
Sports Medicine
Veins & arteries
Velocity
China
Lake Louise
Cerebral hemodynamic characteristics
Acute mountain sickness
High altitude
Online AccessGet full text

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Abstract Purpose We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS). Methods Transcranial Doppler (TCD) sonography examinations were performed between 18 and 24 h after arrival at 3,700 m via plane from 500 m ( n  = 454). A subgroup of 151 subjects received TCD examinations at both altitudes. Results The velocities of the middle cerebral artery, vertebral artery (VA) and basilar artery (BA) increased while the pulsatility indexes (PIs) and resistance indexes (RIs) decreased significantly (all p  < 0.05). Velocities of BA were higher in AMS (AMS+) individuals when compared with non-AMS (AMS−) subjects (systolic velocity: 66 ± 12 vs. 69 ± 15 cm/s, diastolic velocity: 29 ± 7 vs. 31 ± 8 cm/s and mean velocity, 42 ± 9 vs. 44 ± 10 cm/s). AMS was characterized by higher diastolic velocity [ V d_VA (26 ± 4 vs. 25 ± 4, p  = 0.013)] with lower PI and RI (both p  = 0.004) in VA. Furthermore, the asymmetry index (AI) of VAs was significantly lower in the AMS + group [−5.7 % (21.0 %) vs. −2.5 % (17.8 %), p  = 0.016]. The AMS score was closely correlated with the hemodynamic parameters of BA and the V d_VA , PI, RI and AI of VA. Conclusion AMS is associated with alterations in cerebral hemodynamics in the posterior circulation rather than the anterior one, and is characterized by higher blood velocity with lower resistance. In addition, the asymmetry of VAs may be involved in AMS.
AbstractList We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS).PURPOSEWe aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS).Transcranial Doppler (TCD) sonography examinations were performed between 18 and 24 h after arrival at 3,700 m via plane from 500 m (n = 454). A subgroup of 151 subjects received TCD examinations at both altitudes.METHODSTranscranial Doppler (TCD) sonography examinations were performed between 18 and 24 h after arrival at 3,700 m via plane from 500 m (n = 454). A subgroup of 151 subjects received TCD examinations at both altitudes.The velocities of the middle cerebral artery, vertebral artery (VA) and basilar artery (BA) increased while the pulsatility indexes (PIs) and resistance indexes (RIs) decreased significantly (all p < 0.05). Velocities of BA were higher in AMS (AMS+) individuals when compared with non-AMS (AMS-) subjects (systolic velocity: 66 ± 12 vs. 69 ± 15 cm/s, diastolic velocity: 29 ± 7 vs. 31 ± 8 cm/s and mean velocity, 42 ± 9 vs. 44 ± 10 cm/s). AMS was characterized by higher diastolic velocity [V d_VA (26 ± 4 vs. 25 ± 4, p = 0.013)] with lower PI and RI (both p = 0.004) in VA. Furthermore, the asymmetry index (AI) of VAs was significantly lower in the AMS + group [-5.7 % (21.0 %) vs. -2.5 % (17.8 %), p = 0.016]. The AMS score was closely correlated with the hemodynamic parameters of BA and the V d_VA, PI, RI and AI of VA.RESULTSThe velocities of the middle cerebral artery, vertebral artery (VA) and basilar artery (BA) increased while the pulsatility indexes (PIs) and resistance indexes (RIs) decreased significantly (all p < 0.05). Velocities of BA were higher in AMS (AMS+) individuals when compared with non-AMS (AMS-) subjects (systolic velocity: 66 ± 12 vs. 69 ± 15 cm/s, diastolic velocity: 29 ± 7 vs. 31 ± 8 cm/s and mean velocity, 42 ± 9 vs. 44 ± 10 cm/s). AMS was characterized by higher diastolic velocity [V d_VA (26 ± 4 vs. 25 ± 4, p = 0.013)] with lower PI and RI (both p = 0.004) in VA. Furthermore, the asymmetry index (AI) of VAs was significantly lower in the AMS + group [-5.7 % (21.0 %) vs. -2.5 % (17.8 %), p = 0.016]. The AMS score was closely correlated with the hemodynamic parameters of BA and the V d_VA, PI, RI and AI of VA.AMS is associated with alterations in cerebral hemodynamics in the posterior circulation rather than the anterior one, and is characterized by higher blood velocity with lower resistance. In addition, the asymmetry of VAs may be involved in AMS.CONCLUSIONAMS is associated with alterations in cerebral hemodynamics in the posterior circulation rather than the anterior one, and is characterized by higher blood velocity with lower resistance. In addition, the asymmetry of VAs may be involved in AMS.
We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS). Transcranial Doppler (TCD) sonography examinations were performed between 18 and 24 h after arrival at 3,700 m via plane from 500 m (n = 454). A subgroup of 151 subjects received TCD examinations at both altitudes. The velocities of the middle cerebral artery, vertebral artery (VA) and basilar artery (BA) increased while the pulsatility indexes (PIs) and resistance indexes (RIs) decreased significantly (all p < 0.05). Velocities of BA were higher in AMS (AMS+) individuals when compared with non-AMS (AMS-) subjects (systolic velocity: 66 ± 12 vs. 69 ± 15 cm/s, diastolic velocity: 29 ± 7 vs. 31 ± 8 cm/s and mean velocity, 42 ± 9 vs. 44 ± 10 cm/s). AMS was characterized by higher diastolic velocity [V ^sub d_VA^ (26 ± 4 vs. 25 ± 4, p = 0.013)] with lower PI and RI (both p = 0.004) in VA. Furthermore, the asymmetry index (AI) of VAs was significantly lower in the AMS + group [-5.7 % (21.0 %) vs. -2.5 % (17.8 %), p = 0.016]. The AMS score was closely correlated with the hemodynamic parameters of BA and the V ^sub d_VA^, PI, RI and AI of VA. AMS is associated with alterations in cerebral hemodynamics in the posterior circulation rather than the anterior one, and is characterized by higher blood velocity with lower resistance. In addition, the asymmetry of VAs may be involved in AMS.[PUBLICATION ABSTRACT]
We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS). Transcranial Doppler (TCD) sonography examinations were performed between 18 and 24 h after arrival at 3,700 m via plane from 500 m (n = 454). A subgroup of 151 subjects received TCD examinations at both altitudes. The velocities of the middle cerebral artery, vertebral artery (VA) and basilar artery (BA) increased while the pulsatility indexes (PIs) and resistance indexes (RIs) decreased significantly (all p < 0.05). Velocities of BA were higher in AMS (AMS+) individuals when compared with non-AMS (AMS-) subjects (systolic velocity: 66 ± 12 vs. 69 ± 15 cm/s, diastolic velocity: 29 ± 7 vs. 31 ± 8 cm/s and mean velocity, 42 ± 9 vs. 44 ± 10 cm/s). AMS was characterized by higher diastolic velocity [V d_VA (26 ± 4 vs. 25 ± 4, p = 0.013)] with lower PI and RI (both p = 0.004) in VA. Furthermore, the asymmetry index (AI) of VAs was significantly lower in the AMS + group [-5.7 % (21.0 %) vs. -2.5 % (17.8 %), p = 0.016]. The AMS score was closely correlated with the hemodynamic parameters of BA and the V d_VA, PI, RI and AI of VA. AMS is associated with alterations in cerebral hemodynamics in the posterior circulation rather than the anterior one, and is characterized by higher blood velocity with lower resistance. In addition, the asymmetry of VAs may be involved in AMS.
Purpose We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS). Methods Transcranial Doppler (TCD) sonography examinations were performed between 18 and 24 h after arrival at 3,700 m via plane from 500 m ( n  = 454). A subgroup of 151 subjects received TCD examinations at both altitudes. Results The velocities of the middle cerebral artery, vertebral artery (VA) and basilar artery (BA) increased while the pulsatility indexes (PIs) and resistance indexes (RIs) decreased significantly (all p  < 0.05). Velocities of BA were higher in AMS (AMS+) individuals when compared with non-AMS (AMS−) subjects (systolic velocity: 66 ± 12 vs. 69 ± 15 cm/s, diastolic velocity: 29 ± 7 vs. 31 ± 8 cm/s and mean velocity, 42 ± 9 vs. 44 ± 10 cm/s). AMS was characterized by higher diastolic velocity [ V d_VA (26 ± 4 vs. 25 ± 4, p  = 0.013)] with lower PI and RI (both p  = 0.004) in VA. Furthermore, the asymmetry index (AI) of VAs was significantly lower in the AMS + group [−5.7 % (21.0 %) vs. −2.5 % (17.8 %), p  = 0.016]. The AMS score was closely correlated with the hemodynamic parameters of BA and the V d_VA , PI, RI and AI of VA. Conclusion AMS is associated with alterations in cerebral hemodynamics in the posterior circulation rather than the anterior one, and is characterized by higher blood velocity with lower resistance. In addition, the asymmetry of VAs may be involved in AMS.
Author Zhang, Ji-Hang
Huang, Lan
Jin, Jun
Chen, Jian-Fei
Qin, Jun
Tang, Cai-Fa
Bian, Shi-Zhu
Yu, Shi-Yong
Li, Qian-Ning
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  givenname: Jun
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  surname: Huang
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  email: huanglan260@126.com
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/24996805$$D View this record in MEDLINE/PubMed
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Issue 10
Keywords Cerebral hemodynamic characteristics
Acute mountain sickness
High altitude
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
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Communicated by Massimo Pagani.
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SSID ssj0008218
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Snippet Purpose We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS). Methods Transcranial Doppler (TCD) sonography...
We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS). Transcranial Doppler (TCD) sonography examinations were...
We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS). Transcranial Doppler (TCD) sonography examinations were...
We aimed at identifying the cerebral hemodynamic characteristics of acute mountain sickness (AMS).PURPOSEWe aimed at identifying the cerebral hemodynamic...
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StartPage 2193
SubjectTerms Adolescent
Adult
Age Factors
Altitude
Altitude Sickness - physiopathology
Asymmetry
Biomedical and Life Sciences
Biomedicine
Cardiology
Case-Control Studies
Cerebrovascular Circulation
Headaches
Hemodynamics
Human Physiology
Humans
Hypoxia
Male
Middle Aged
Occupational Medicine/Industrial Medicine
Original
Original Article
Sports Medicine
Veins & arteries
Velocity
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Title Cerebral hemodynamic characteristics of acute mountain sickness upon acute high-altitude exposure at 3,700 m in young Chinese men
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