Bridging the Gap between Mechanics and Genetics in Cortical Folding: ECM as a Major Driving Force

Folding of the cerebral cortex results from interrelated biological and mechanical processes that are incompletely understood. In this issue, Long et al. identify the key roles of HAPLN1, lumican, collagen I, and HA in relationship with changes in tissue stiffness. Folding of the cerebral cortex res...

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Bibliographic Details
Published inNeuron (Cambridge, Mass.) Vol. 99; no. 4; pp. 625 - 627
Main Authors Wianny, Florence, Kennedy, Henry, Dehay, Colette
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 22.08.2018
Elsevier Limited
Elsevier
Subjects
Brain
Cerebral cortex
Collagen
Collagen (type I)
Defects
Extracellular Matrix
Gene expression
Humans
Hyaluronic Acid
Kinases
Life Sciences
Lumican
Mechanical Phenomena
Mechanics
Neocortex
Neurobiology
Neurons and Cognition
Proteins
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Summary:Folding of the cerebral cortex results from interrelated biological and mechanical processes that are incompletely understood. In this issue, Long et al. identify the key roles of HAPLN1, lumican, collagen I, and HA in relationship with changes in tissue stiffness. Folding of the cerebral cortex results from interrelated biological and mechanical processes that are incompletely understood. In this issue, Long et al. identify the key roles of HAPLN1, lumican, collagen I, and HA in relationship with changes in tissue stiffness.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2018.08.012