From sperm to offspring: Assessing the heritable genetic consequences of paternal smoking and potential public health impacts

• Published in: Mutation research. Reviews in mutation research Vol. 773; pp. 26 - 50
• Main Authors: Beal, Marc A., Yauk, Carole L., Marchetti, Francesco
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2017
• Subjects: Aneuploidy; Animals; Cigarette; de novo mutation; DNA Damage; Female; Genetic Diseases, Inborn - etiology; Genetic Diseases, Inborn - pathology; Genomic Instability; Humans; Infertility, Male - pathology; Intellectual disability; Male; Models, Animal; Mutation; Paternal Inheritance; Pregnancy; Prenatal Exposure Delayed Effects; Public Health; Smoking - adverse effects; Socioeconomic Factors; Sperm; Spermatozoa - drug effects; Spermatozoa - pathology; Tobacco; Tobacco Products; Cigarette; de novo mutation; Aneuploidy; Tobacco; Intellectual disability; Sperm

Individuals who smoke generally do so with the knowledge of potential consequences to their own health. What is rarely considered are the effects of smoking on their future children. The objective of this work was to review the scientific literature on the effects of paternal smoking on sperm and as...