Genetic Variation in the Peroxisome Proliferator Activated Receptor-Gamma Gene Is Associated with Histologically Advanced NAFLD

• Published in: Digestive diseases and sciences Vol. 57; no. 4; pp. 952 - 957
• Main Authors: Gawrieh, Samer, Marion, Miranda C., Komorowski, Richard, Wallace, James, Charlton, Michael, Kissebah, Ahmed, Langefeld, Carl D., Olivier, Michael
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.04.2012; Springer; Springer Nature B.V
• Subjects: Adult; Biochemistry; Fatty Liver - genetics; Fatty Liver - pathology; Female; Formaldehyde; Gastroenterology; Gene Frequency; Genes; Genetic aspects; Genotype; Haplotypes; Hepatology; Humans; Liver; Liver - pathology; Liver diseases; Male; Medicine; Medicine & Public Health; Middle Aged; Non-alcoholic Fatty Liver Disease; Oncology; Original Article; Physiological aspects; Polymorphism, Single Nucleotide; PPAR gamma - genetics; Transplant Surgery; Type 2 diabetes; NAFLD; Gene; SNP; NASH; PPAR gamma; Polymorphism

Background The peroxisome proliferator activated receptor-gamma ( PPARG ) is a nuclear receptor that regulates adipocyte differentiation, insulin sensitivity and lipid metabolism, thus, it represents a good candidate gene for non-alcoholic fatty liver disease (NAFLD). Purpose and Method We investiga...