Novel Ring Structure in the gp41 Trimer of Human Immunodeficiency Virus Type 1 That Modulates Sensitivity and Resistance to Broadly Neutralizing Antibodies

Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inJournal of Virology Vol. 83; no. 15; pp. 7728 - 7738
Main Authors O'ROURKE, Sara M, SCHWEIGHARDT, Becky, SCOTT, William G, WRIN, Terri, FONSECA, Dora P. A. J, SINANGIL, Faruk, BERMAN, Phillip W
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.08.2009
American Society for Microbiology (ASM)
Subjects
Amino Acid Sequence
Antibodies, Viral - immunology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
HIV Envelope Protein gp41 - chemistry
HIV Envelope Protein gp41 - genetics
HIV Envelope Protein gp41 - immunology
HIV Infections - immunology
HIV Infections - virology
HIV-1 - chemistry
HIV-1 - genetics
HIV-1 - immunology
Human immunodeficiency virus 1
Humans
Microbiology
Miscellaneous
Molecular Conformation
Molecular Sequence Data
Mutation
Neutralization Tests
Pathogenesis and Immunity
Protein Conformation
Virology
Immunopathology
HIV-1 virus
Retroviridae
AIDS
Immune deficiency
Lentivirus
Neutralizing antibody
Virology
Infection
Virus
Sensitivity resistance
Viral disease
Human immunodeficiency virus
Online AccessGet full text

Cover

Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList The identification of the determinants of sensitivity and resistance to broadly neutralizing antibodies is a high priority for human immunodeficiency virus (HIV) research. An analysis of the swarm of closely related envelope protein variants in an HIV-infected individual revealed a mutation that markedly affected sensitivity to neutralization by antibodies and antiviral entry inhibitors targeting both gp41 and gp120. This mutation mapped to the C34 helix of gp41 and disrupted an unexplored structural feature consisting of a ring of hydrogen bonds in the gp41 trimer. This mutation appeared to affect the assembly of the six-helix bundle required for virus fusion and to alter the conformational equilibria so as to favor the prehairpin intermediate conformation required for the binding of the membrane proximal external region-specific neutralizing antibodies 2F5 and 4E10 and the antiviral drug enfuvirtide (Fuzeon). The QUOTATION_MARKswarm analysisQUOTATION_MARK method we describe furthers our understanding of the relationships among the structure, function, and antigenicity of the HIV envelope protein and represents a new approach to the identification of vaccine antigens.
The identification of the determinants of sensitivity and resistance to broadly neutralizing antibodies is a high priority for human immunodeficiency virus (HIV) research. An analysis of the swarm of closely related envelope protein variants in an HIV-infected individual revealed a mutation that markedly affected sensitivity to neutralization by antibodies and antiviral entry inhibitors targeting both gp41 and gp120. This mutation mapped to the C34 helix of gp41 and disrupted an unexplored structural feature consisting of a ring of hydrogen bonds in the gp41 trimer. This mutation appeared to affect the assembly of the six-helix bundle required for virus fusion and to alter the conformational equilibria so as to favor the prehairpin intermediate conformation required for the binding of the membrane proximal external region-specific neutralizing antibodies 2F5 and 4E10 and the antiviral drug enfuvirtide (Fuzeon). The "swarm analysis" method we describe furthers our understanding of the relationships among the structure, function, and antigenicity of the HIV envelope protein and represents a new approach to the identification of vaccine antigens.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Author Faruk Sinangil
Becky Schweighardt
Phillip W. Berman
Terri Wrin
William G. Scott
Sara M. O'Rourke
Dora P. A. J. Fonseca
AuthorAffiliation Department of Biomolecular Engineering, University of California, Santa Cruz, California 95064, 1 Monogram Biosciences, South San Francisco, California 94080, 2 Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, 3 Global Solutions for Infectious Diseases, South San Francisco, California 94080 4
AuthorAffiliation_xml – name: Department of Biomolecular Engineering, University of California, Santa Cruz, California 95064, 1 Monogram Biosciences, South San Francisco, California 94080, 2 Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, 3 Global Solutions for Infectious Diseases, South San Francisco, California 94080 4
Author_xml – sequence: 1
  givenname: Sara M
  surname: O'ROURKE
  fullname: O'ROURKE, Sara M
  organization: Department of Biomolecular Engineering, University of California, Santa Cruz, California 95064, United States
– sequence: 2
  givenname: Becky
  surname: SCHWEIGHARDT
  fullname: SCHWEIGHARDT, Becky
  organization: Monogram Biosciences, South San Francisco, California 94080, United States
– sequence: 3
  givenname: William G
  surname: SCOTT
  fullname: SCOTT, William G
  organization: Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, Califomia 95064, United States
– sequence: 4
  givenname: Terri
  surname: WRIN
  fullname: WRIN, Terri
  organization: Monogram Biosciences, South San Francisco, California 94080, United States
– sequence: 5
  givenname: Dora P. A. J
  surname: FONSECA
  fullname: FONSECA, Dora P. A. J
  organization: Department of Biomolecular Engineering, University of California, Santa Cruz, California 95064, United States
– sequence: 6
  givenname: Faruk
  surname: SINANGIL
  fullname: SINANGIL, Faruk
  organization: Global Solutions for Infectious Diseases, South San Francisco, California 94080, United States
– sequence: 7
  givenname: Phillip W
  surname: BERMAN
  fullname: BERMAN, Phillip W
  organization: Department of Biomolecular Engineering, University of California, Santa Cruz, California 95064, United States
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21737838$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/19474108$$D View this record in MEDLINE/PubMed
BookMark eNqF0c1u1DAUBeAIFdEf2LFGFhKsmOJrO3GyQSoV0EGlSO1QsbMc52bGVWIPtjNoeBVeloQZFVix8sKfjs7VOc4OnHeYZU-BngKw8vXH2_kppUVZzmj1IDsCWpWzPAdxkB1Rytgs5-XXw-w4xjtKQYhCPMoOoRJSAC2Psp9XfoMdubZuSW5SGEwaAhLrSFohWa4FkEWwPQbiW3Ix9NqRed8PzjfYWmPRmS25tWGIZLFdIxn1SifyyTdDpxNGcoMu2mQ3Nm2Jdg25xmhj0s4gSZ68DV433ZZc4ZCC7uyPqcWZS7b2jcX4OHvY6i7ik_17kn15_25xfjG7_Pxhfn52OTNC0jTTgEznjWB5xbiEWiNokECh0Mh4C0xUhlY117IRXAAKI1ndUtC1MKatK36Svdnlroe6x8agm9qo9Xi4DlvltVX__ji7Uku_UUzSsuBTwMt9QPDfBoxJ9TYa7Drt0A9RFVIUBWfwXzgSlgOUI3y1gyb4GAO2922Aqml2Nc6ufs-u6FTg2d8X_MH7nUfwYg90NLprwziBjfeOgeSy5JN7vnMru1x9twGVjr2621hVcgW5kpKV_BelTcWX
CitedBy_id crossref_primary_10_1111_j_1747_0285_2012_01423_x
crossref_primary_10_1371_journal_pcbi_1000955
crossref_primary_10_1371_journal_pone_0119608
crossref_primary_10_1074_jbc_M114_554089
crossref_primary_10_1128_JVI_00953_12
crossref_primary_10_1016_j_virol_2011_07_015
crossref_primary_10_1016_j_molimm_2014_06_025
crossref_primary_10_1186_s12985_017_0704_x
crossref_primary_10_1128_JVI_00790_10
crossref_primary_10_1016_j_virol_2010_10_007
crossref_primary_10_1016_j_virol_2014_03_015
crossref_primary_10_1371_journal_pcbi_1006952
crossref_primary_10_1128_JVI_01352_12
crossref_primary_10_1128_jvi_01878_21
crossref_primary_10_1371_journal_ppat_1002101
crossref_primary_10_1016_j_virol_2013_07_024
crossref_primary_10_1016_j_molimm_2016_07_003
crossref_primary_10_1128_JVI_00304_19
crossref_primary_10_1186_1742_4690_11_41
crossref_primary_10_1371_journal_pone_0018233
crossref_primary_10_1016_j_virol_2011_09_032
crossref_primary_10_1371_journal_pone_0037157
crossref_primary_10_1128_JVI_00174_17
Cites_doi 10.1089/aid.2008.0085
10.1128/JVI.00239-07
10.1038/337525a0
10.1016/j.jsb.2003.10.014
10.1126/science.7973652
10.1128/JVI.02036-08
10.1128/JVI.02631-08
10.1128/JVI.00124-08
10.1128/jvi.70.2.1100-1108.1996
10.1128/JVI.76.15.7595-7606.2002
10.1016/j.immuni.2007.11.018
10.1126/science.1161000
10.1128/JVI.75.22.10892-10905.2001
10.1038/nature01470
10.1073/pnas.88.16.7056
10.1016/j.jmb.2007.12.001
10.1128/JVI.74.2.627-643.2000
10.1023/A:1010463005396
10.1038/387426a0
10.1128/JVI.02132-08
10.1128/JVI.79.18.11693-11704.2005
10.1073/pnas.87.17.6574
10.1128/JVI.00575-06
10.1016/j.jviromet.2006.04.009
10.1089/aid.2006.22.1014
10.1126/science.8356453
10.1128/JVI.02749-06
10.1038/nrmicro1326
10.1016/S0092-8674(00)80205-6
10.1086/428404
10.1128/JVI.76.23.11953-11959.2002
10.1128/jvi.67.11.6642-6647.1993
10.1073/pnas.95.11.6032
10.1038/nature05580
10.1107/S0907444902016657
10.1073/pnas.0630530100
10.1073/pnas.0800255105
10.1073/pnas.0802203105
10.1083/jcb.140.2.315
10.1056/NEJMoa035211
10.1128/JVI.79.2.1252-1261.2005
10.1086/514055
10.1038/ni0304-233
10.1097/00002030-200309050-00005
10.1089/08892220152741450
10.1016/S0092-8674(00)81430-0
10.1073/pnas.89.21.10537
10.1074/jbc.M609148200
10.1016/S0065-2776(08)60674-4
10.1016/j.immuni.2004.12.011
10.1128/JVI.79.16.10108-10125.2005
10.1128/JVI.01759-06
10.1128/AAC.00853-06
10.1097/QAI.0b013e318074eb5a
10.1371/journal.pmed.0050009
ContentType Journal Article
Copyright 2009 INIST-CNRS
Copyright © 2009, American Society for Microbiology
Copyright_xml – notice: 2009 INIST-CNRS
– notice: Copyright © 2009, American Society for Microbiology
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QO
7T5
7T7
7U9
8FD
C1K
FR3
H94
P64
7X8
5PM
DOI 10.1128/JVI.00688-09
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Biotechnology Research Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Virology and AIDS Abstracts
Biotechnology Research Abstracts
Technology Research Database
AIDS and Cancer Research Abstracts
Immunology Abstracts
Engineering Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
MEDLINE - Academic
DatabaseTitleList Virology and AIDS Abstracts
MEDLINE

CrossRef
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1098-5514
EndPage 7738
ExternalDocumentID 10_1128_JVI_00688_09
19474108
21737838
jvi_83_15_7728
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-~X
.55
.GJ
08R
0R~
18M
29L
2WC
39C
3O-
4.4
41~
53G
5GY
5RE
5VS
6TJ
85S
AAUGY
AAYJJ
ABPPZ
ABPTK
ACGFO
ACNCT
ADBBV
AENEX
AFDAS
AFFNX
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CS3
D0S
DIK
E3Z
EBS
EJD
F20
F5P
FRP
GX1
H13
HYE
HZ~
IH2
IQODW
KQ8
MVM
N9A
O9-
OHT
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TR2
UCJ
UPT
VH1
W2D
W8F
WH7
WOQ
X7M
XFK
Y6R
YQT
ZA5
ZGI
ZXP
~02
~KM
AGVNZ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QO
7T5
7T7
7U9
8FD
C1K
FR3
H94
P64
7X8
5PM
ID FETCH-LOGICAL-c470t-a1e2a5d42592371bae1a171016ae23f1249c09b3a7d4341e4c72bf01ab4ccfb93
IEDL.DBID RPM
ISSN 0022-538X
IngestDate Tue Sep 17 21:28:03 EDT 2024
Sun Sep 29 07:28:50 EDT 2024
Fri Oct 25 00:52:29 EDT 2024
Fri Dec 06 02:31:42 EST 2024
Sat Nov 02 12:15:08 EDT 2024
Sun Oct 22 16:05:40 EDT 2023
Wed May 18 15:25:40 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 15
Keywords Immunopathology
HIV-1 virus
Retroviridae
AIDS
Immune deficiency
Lentivirus
Neutralizing antibody
Virology
Infection
Virus
Sensitivity resistance
Viral disease
Human immunodeficiency virus
Language English
License CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c470t-a1e2a5d42592371bae1a171016ae23f1249c09b3a7d4341e4c72bf01ab4ccfb93
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Corresponding author. Mailing address: Department of Biomolecular Engineering, Baskin School of Engineering, University of California, Santa Cruz, 1156 High Street, MS-SOE2, Santa Cruz, CA 95064. Phone: (831) 459-3529. Fax: (831) 459-1970. E-mail: pwb@soe.ucsc.edu
OpenAccessLink https://jvi.asm.org/content/jvi/83/15/7728.full.pdf
PMID 19474108
PQID 21325118
PQPubID 23462
PageCount 11
ParticipantIDs pascalfrancis_primary_21737838
proquest_miscellaneous_67466321
highwire_asm_jvi_83_15_7728
pubmed_primary_19474108
pubmedcentral_primary_oai_pubmedcentral_nih_gov_2708639
crossref_primary_10_1128_JVI_00688_09
proquest_miscellaneous_21325118
PublicationCentury 2000
PublicationDate 2009-08-01
PublicationDateYYYYMMDD 2009-08-01
PublicationDate_xml – month: 08
  year: 2009
  text: 2009-08-01
  day: 01
PublicationDecade 2000
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Journal of Virology
PublicationTitleAlternate J Virol
PublicationYear 2009
Publisher American Society for Microbiology
American Society for Microbiology (ASM)
Publisher_xml – name: American Society for Microbiology
– name: American Society for Microbiology (ASM)
References e_1_3_2_26_2
e_1_3_2_49_2
e_1_3_2_28_2
e_1_3_2_41_2
e_1_3_2_20_2
e_1_3_2_43_2
e_1_3_2_22_2
e_1_3_2_45_2
e_1_3_2_24_2
e_1_3_2_47_2
e_1_3_2_9_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
e_1_3_2_18_2
e_1_3_2_39_2
e_1_3_2_54_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_52_2
e_1_3_2_5_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_58_2
e_1_3_2_3_2
e_1_3_2_14_2
e_1_3_2_35_2
e_1_3_2_56_2
e_1_3_2_50_2
e_1_3_2_27_2
e_1_3_2_48_2
e_1_3_2_29_2
e_1_3_2_40_2
e_1_3_2_21_2
e_1_3_2_42_2
e_1_3_2_23_2
e_1_3_2_44_2
e_1_3_2_25_2
e_1_3_2_46_2
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_53_2
e_1_3_2_32_2
e_1_3_2_51_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_57_2
e_1_3_2_4_2
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_55_2
e_1_3_2_2_2
References_xml – ident: e_1_3_2_28_2
  doi: 10.1089/aid.2008.0085
– ident: e_1_3_2_23_2
  doi: 10.1128/JVI.00239-07
– ident: e_1_3_2_12_2
  doi: 10.1038/337525a0
– ident: e_1_3_2_49_2
  doi: 10.1016/j.jsb.2003.10.014
– ident: e_1_3_2_11_2
  doi: 10.1126/science.7973652
– ident: e_1_3_2_43_2
  doi: 10.1128/JVI.02036-08
– ident: e_1_3_2_45_2
  doi: 10.1128/JVI.02631-08
– ident: e_1_3_2_27_2
  doi: 10.1128/JVI.00124-08
– ident: e_1_3_2_48_2
  doi: 10.1128/jvi.70.2.1100-1108.1996
– ident: e_1_3_2_8_2
  doi: 10.1128/JVI.76.15.7595-7606.2002
– ident: e_1_3_2_47_2
  doi: 10.1016/j.immuni.2007.11.018
– ident: e_1_3_2_19_2
  doi: 10.1126/science.1161000
– ident: e_1_3_2_58_2
  doi: 10.1128/JVI.75.22.10892-10905.2001
– ident: e_1_3_2_50_2
  doi: 10.1038/nature01470
– ident: e_1_3_2_4_2
  doi: 10.1073/pnas.88.16.7056
– ident: e_1_3_2_30_2
  doi: 10.1016/j.jmb.2007.12.001
– ident: e_1_3_2_6_2
  doi: 10.1128/JVI.74.2.627-643.2000
– ident: e_1_3_2_33_2
  doi: 10.1023/A:1010463005396
– ident: e_1_3_2_52_2
  doi: 10.1038/387426a0
– ident: e_1_3_2_2_2
  doi: 10.1128/JVI.02132-08
– ident: e_1_3_2_37_2
  doi: 10.1128/JVI.79.18.11693-11704.2005
– ident: e_1_3_2_16_2
  doi: 10.1073/pnas.87.17.6574
– ident: e_1_3_2_36_2
  doi: 10.1128/JVI.00575-06
– ident: e_1_3_2_17_2
– ident: e_1_3_2_42_2
  doi: 10.1016/j.jviromet.2006.04.009
– ident: e_1_3_2_25_2
  doi: 10.1089/aid.2006.22.1014
– ident: e_1_3_2_56_2
  doi: 10.1126/science.8356453
– ident: e_1_3_2_18_2
  doi: 10.1128/JVI.02749-06
– ident: e_1_3_2_29_2
  doi: 10.1038/nrmicro1326
– ident: e_1_3_2_14_2
  doi: 10.1016/S0092-8674(00)80205-6
– ident: e_1_3_2_21_2
  doi: 10.1086/428404
– ident: e_1_3_2_32_2
  doi: 10.1128/JVI.76.23.11953-11959.2002
– ident: e_1_3_2_40_2
  doi: 10.1128/jvi.67.11.6642-6647.1993
– ident: e_1_3_2_51_2
  doi: 10.1073/pnas.95.11.6032
– ident: e_1_3_2_55_2
  doi: 10.1038/nature05580
– ident: e_1_3_2_3_2
  doi: 10.1107/S0907444902016657
– ident: e_1_3_2_41_2
  doi: 10.1073/pnas.0630530100
– ident: e_1_3_2_38_2
– ident: e_1_3_2_22_2
  doi: 10.1073/pnas.0800255105
– ident: e_1_3_2_26_2
  doi: 10.1073/pnas.0802203105
– ident: e_1_3_2_39_2
  doi: 10.1083/jcb.140.2.315
– ident: e_1_3_2_31_2
  doi: 10.1056/NEJMoa035211
– ident: e_1_3_2_57_2
  doi: 10.1128/JVI.79.2.1252-1261.2005
– ident: e_1_3_2_5_2
  doi: 10.1086/514055
– ident: e_1_3_2_10_2
  doi: 10.1038/ni0304-233
– ident: e_1_3_2_20_2
  doi: 10.1097/00002030-200309050-00005
– ident: e_1_3_2_46_2
  doi: 10.1089/08892220152741450
– ident: e_1_3_2_15_2
  doi: 10.1016/S0092-8674(00)81430-0
– ident: e_1_3_2_54_2
  doi: 10.1073/pnas.89.21.10537
– ident: e_1_3_2_35_2
  doi: 10.1074/jbc.M609148200
– ident: e_1_3_2_9_2
  doi: 10.1016/S0065-2776(08)60674-4
– ident: e_1_3_2_13_2
  doi: 10.1016/j.immuni.2004.12.011
– ident: e_1_3_2_34_2
  doi: 10.1128/JVI.79.16.10108-10125.2005
– ident: e_1_3_2_24_2
  doi: 10.1128/JVI.01759-06
– ident: e_1_3_2_53_2
  doi: 10.1128/AAC.00853-06
– ident: e_1_3_2_44_2
  doi: 10.1097/QAI.0b013e318074eb5a
– ident: e_1_3_2_7_2
  doi: 10.1371/journal.pmed.0050009
SSID ssj0014464
Score 2.1302915
Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
The identification of the determinants of sensitivity and resistance to broadly neutralizing antibodies is a high priority for human immunodeficiency virus...
SourceID pubmedcentral
proquest
crossref
pubmed
pascalfrancis
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 7728
SubjectTerms Amino Acid Sequence
Antibodies, Viral - immunology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
HIV Envelope Protein gp41 - chemistry
HIV Envelope Protein gp41 - genetics
HIV Envelope Protein gp41 - immunology
HIV Infections - immunology
HIV Infections - virology
HIV-1 - chemistry
HIV-1 - genetics
HIV-1 - immunology
Human immunodeficiency virus 1
Humans
Microbiology
Miscellaneous
Molecular Conformation
Molecular Sequence Data
Mutation
Neutralization Tests
Pathogenesis and Immunity
Protein Conformation
Virology
Title Novel Ring Structure in the gp41 Trimer of Human Immunodeficiency Virus Type 1 That Modulates Sensitivity and Resistance to Broadly Neutralizing Antibodies
URI http://jvi.asm.org/content/83/15/7728.abstract
https://www.ncbi.nlm.nih.gov/pubmed/19474108
https://search.proquest.com/docview/21325118
https://search.proquest.com/docview/67466321
https://pubmed.ncbi.nlm.nih.gov/PMC2708639
Volume 83
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtswECSSAAV6KfqumtTdQ3tUbEmUKR2DoEGcwkaRF3wjKIpsVNiSYckB0l_Jz3aXktK4aC89e20Q3iV2hhzOMvYpGmejPNSxn9o08Xmcxn4WxtYPlE011ovVlh4KT2fj0yt-No_nOyzu38I40b7OisNysTwsixunrVwt9bDXiQ2_TY9DgUA8Soe7bBfbb0_Ru6sD5De8twjH3Tzv1e5hMjy7npCOK6ELf-cWyrGf0mDJxy2ptwkmlaSq8Y-y7YSLv0HQP5WUj1rTyXP2rMOUcNSu_QXbMeVL9qSdMnn3it3PqluzgHNsUnDh7GI3awNFCYj94PuKB3BJHv9rqCy4M32Y0KORKjfkLkFPM-G6WG9qIM4KGH2jGphWOQ3-MjVckAS-nUEBqszh3NSESbGYoKkAab7KF3cwMxt3pvKTVnFUNkVWkX7xNbs6-XJ5fOp3Mxl8zcWo8VVgQhXnuNMRGYogUyZQgaAjAGXCyNIoaz1Ks0iJnGODNFyLMLOjQGVca5ul0Ru2V1alecdAJGTVk-c6DhXHmiCntTyIjU3HWiHO89jnPi1y1VpvSEdZwkRiJqXLpBylHtvvcyZVvZQ_bguZRDKIJTKHxGODrTQ-_BRysUgkEQZ87PMqcWvRfYkqTbWpMSJyBOzfEWPBEbGFgcfetnXwe6FdbXlMbFXIQwDZem9_gtXu7L276n7_39_cZ0_bOy-SKR6wPaws8wGhU5MNkDRMvg7chvkFxvQcdQ
link.rule.ids 230,314,727,780,784,885,27924,27925,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLXGEIIXxDdhsPkBHrPGiV0nj9PE1I61Qls39c1yHJsFtUnVtJPGX-HPcq_TjBXBC8-9razeY91z7eNzCfmY9POoiI0IM5elIReZCPNYuJBplxnAizMOHwqPxv3BJT-diukOEd1bGC_aN3l5WM3mh1V57bWVi7npdTqx3tfRcSyBiCdZ7wF5KBKZsa5J31weQIfDO5Nw2M_TTu8ep73TqyEquVK88vd-oRwqKo6WvF-UOqNg1EnqBv4q1864-BsJ_VNLea84nTwjTzeskh61q39Odmz1gjxq50zeviQ_x_WNndFzKFP0whvGrpeWlhUF9ke_LTijE3T5X9LaUX-qT4f4bKQuLPpL4ONMelUu1w3FrpVC9LVe0VFd4Ogv29ALFMG3Uyiorgp6bhtkpQAnuqopNPq6mN3SsV37U5UfuIqjalXmNSoYX5HLk8-T40G4mcoQGi6jVaiZjbUoYK8DN5Qs15ZpJvEQQNs4cTjM2kRZnmhZcCiRlhsZ5y5iOufGuDxLXpPdqq7sW0JlimY9RWFErDmgAr3WCiasy_pGA9MLyKcuLWrRmm8o37TEqYJMKp9JFWUB2etypnQzV99vSpUmigkFvUMakP2tNN79FHRjiUwTCDjo8qpgc-GNia5svW4gIvEt2L8j-pIDZ4tZQN60OPi90A22AiK3EHIXgMbe258A3r3B9wbf7_77mwfk8WAyOlNnw_GXPfKkvQFD0eJ7sgsosx-ASK3yfb9tfgEkOh7R
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9NAEF1BEYgL4htTaOcARzexvY7tY1WImkKiql_KbbXeD2qU2FGcVCp_hT_LzNouCYIL50wsJ_NW82b37RvGPkSDvK9DFfuZzVKfx1ns52Fs_UDaTCFerLJ0UXg8GRxf8pNpPN0Y9eVE-yovDsrZ_KAsrp22cjFXvU4n1jsdH4UJEvEo6y207d1nD-IIQdY16u0BAnY5vDMKxzU97TTvYdo7uRqRmiulY3_nGcqxqtJ4yc3C1JkFk1ZS1vh32WbOxd-I6J96yo0CNXzKnrTMEg6bX_CM3TPlc_awmTV5-4L9nFQ3ZgZnWKrg3JnGrpcGihKQAcK3BQ_ggpz-l1BZcDv7MKKrI5U25DFBFzThqliua6DOFTD6Wq5gXGka_2VqOCchfDOJAmSp4czUxEwRUrCqAJt9qWe3MDFrt7Pyg97isFwVeUUqxpfscvj54ujYbycz-Ion_ZUvAxPKWON6R36YBLk0gQwS2giQJowsDbRW_SyPZKI5lknDVRLmth_InCtl8yx6xXbKqjRvGCQpGfZoreJQckQG-a3pIDY2GyiJbM9jH7u0iEVjwCFc4xKmAjMpXCZFP_PYbpczIeu5-H5TiDQSQSywf0g9treVxrtHYUcWJWmEAftdXgUuMDo1kaWp1jVGRK4N-3fEIOHI28LAY68bHPx-0RZbHku2EHIXQObe258g5p3Jd4vxt__9zX326PTTUHwdTb7sssfNIRjpFt-xHQSZeY9capXvuVXzCy9JH-Q
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+Ring+Structure+in+the+gp41+Trimer+of+Human+Immunodeficiency+Virus+Type+1+That+Modulates+Sensitivity+and+Resistance+to+Broadly+Neutralizing+Antibodies&rft.jtitle=Journal+of+virology&rft.au=O%27Rourke%2C+Sara+M.&rft.au=Schweighardt%2C+Becky&rft.au=Scott%2C+William+G.&rft.au=Wrin%2C+Terri&rft.date=2009-08-01&rft.pub=American+Society+for+Microbiology+%28ASM%29&rft.issn=0022-538X&rft.eissn=1098-5514&rft.volume=83&rft.issue=15&rft.spage=7728&rft.epage=7738&rft_id=info:doi/10.1128%2FJVI.00688-09&rft_id=info%3Apmid%2F19474108&rft.externalDBID=PMC2708639
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon