Betulinic acid inhibits cell proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose condition

• Published in: Biomedicine & pharmacotherapy Vol. 80; pp. 338 - 342
• Main Authors: Liu, Chun-mei, Qi, Xue-lin, Yang, Ya-feng, Zhang, Xiu-de
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.05.2016
• Subjects: Animals; Betulinic acid; Cell Cycle Checkpoints - drug effects; Cell Cycle Proteins - metabolism; Cell Proliferation - drug effects; Cells, Cultured; Diabetic nephropathy; Extracellular Signal-Regulated MAP Kinases - metabolism; Fibronectin; Fibronectins - metabolism; Glucose - pharmacology; Internal Medicine; Medical Education; Mesangial cells (MCs); Mesangial Cells - cytology; Mesangial Cells - drug effects; Mesangial Cells - enzymology; Mesangial Cells - metabolism; Mice; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphorylation - drug effects; Rats; Triterpenes - pharmacology; Diabetic nephropathy; Mesangial cells (MCs); Fibronectin; Betulinic acid

[Display omitted] Glomerular mesangial cells (MCs) proliferation and extracellular matrix (ECM) accumulation have been recognized as major pathogenic events in the progression of diabetic nephropathy. Betulinic acid (BA), (3β-hydroxy-lup-20(29)-en-28-oic acid), is a naturally occurring pentacyclic l...