Transcriptomic profile of cystic fibrosis airway epithelial cells undergoing repair
Pathological remodeling of the airway epithelium is commonly observed in Cystic Fibrosis (CF). The different cell types that constitute the airway epithelium are regenerated upon injury to restore integrity and maintenance of the epithelium barrier function. The molecular signature of tissue repair...
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Published in | Scientific data Vol. 6; no. 1; pp. 240 - 7 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
29.10.2019
Nature Publishing Group |
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Abstract | Pathological remodeling of the airway epithelium is commonly observed in Cystic Fibrosis (CF). The different cell types that constitute the airway epithelium are regenerated upon injury to restore integrity and maintenance of the epithelium barrier function. The molecular signature of tissue repair in CF airway epithelial cells has, however, not well been investigated in primary cultures. We therefore collected RNA-seq data from well-differentiated primary cultures of bronchial human airway epithelial cells (HAECs) of CF (F508del/F508del) and non-CF (NCF) origins before and after mechanical wounding, exposed or not to flagellin. We identified the expression changes with time of repair of genes, the products of which are markers of the different cell types that constitute the airway epithelium (basal, suprabasal, intermediate, secretory, goblet and ciliated cells as well as ionocytes). Researchers in the CF field may benefit from this transcriptomic profile, which covers the initial steps of wound repair and revealed differences in this process between CF and NCF cultures.
Measurement(s)
messenger RNA
Technology Type(s)
RNA sequencing
Factor Type(s)
exposure to flagellin • cystic fibrosis versus non-cystic fibrosis • mechanical wounding
Sample Characteristic - Organism
Homo sapiens
Machine-accessible metadata file describing the reported data:
https://doi.org/10.6084/m9.figshare.9944675 |
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AbstractList | Pathological remodeling of the airway epithelium is commonly observed in Cystic Fibrosis (CF). The different cell types that constitute the airway epithelium are regenerated upon injury to restore integrity and maintenance of the epithelium barrier function. The molecular signature of tissue repair in CF airway epithelial cells has, however, not well been investigated in primary cultures. We therefore collected RNA-seq data from well-differentiated primary cultures of bronchial human airway epithelial cells (HAECs) of CF (F508del/F508del) and non-CF (NCF) origins before and after mechanical wounding, exposed or not to flagellin. We identified the expression changes with time of repair of genes, the products of which are markers of the different cell types that constitute the airway epithelium (basal, suprabasal, intermediate, secretory, goblet and ciliated cells as well as ionocytes). Researchers in the CF field may benefit from this transcriptomic profile, which covers the initial steps of wound repair and revealed differences in this process between CF and NCF cultures. Pathological remodeling of the airway epithelium is commonly observed in Cystic Fibrosis (CF). The different cell types that constitute the airway epithelium are regenerated upon injury to restore integrity and maintenance of the epithelium barrier function. The molecular signature of tissue repair in CF airway epithelial cells has, however, not well been investigated in primary cultures. We therefore collected RNA-seq data from well-differentiated primary cultures of bronchial human airway epithelial cells (HAECs) of CF (F508del/F508del) and non-CF (NCF) origins before and after mechanical wounding, exposed or not to flagellin. We identified the expression changes with time of repair of genes, the products of which are markers of the different cell types that constitute the airway epithelium (basal, suprabasal, intermediate, secretory, goblet and ciliated cells as well as ionocytes). Researchers in the CF field may benefit from this transcriptomic profile, which covers the initial steps of wound repair and revealed differences in this process between CF and NCF cultures. Measurement(s) messenger RNA Technology Type(s) RNA sequencing Factor Type(s) exposure to flagellin • cystic fibrosis versus non-cystic fibrosis • mechanical wounding Sample Characteristic - Organism Homo sapiens Machine-accessible metadata file describing the reported data: 10.6084/m9.figshare.9944675 Pathological remodeling of the airway epithelium is commonly observed in Cystic Fibrosis (CF). The different cell types that constitute the airway epithelium are regenerated upon injury to restore integrity and maintenance of the epithelium barrier function. The molecular signature of tissue repair in CF airway epithelial cells has, however, not well been investigated in primary cultures. We therefore collected RNA-seq data from well-differentiated primary cultures of bronchial human airway epithelial cells (HAECs) of CF (F508del/F508del) and non-CF (NCF) origins before and after mechanical wounding, exposed or not to flagellin. We identified the expression changes with time of repair of genes, the products of which are markers of the different cell types that constitute the airway epithelium (basal, suprabasal, intermediate, secretory, goblet and ciliated cells as well as ionocytes). Researchers in the CF field may benefit from this transcriptomic profile, which covers the initial steps of wound repair and revealed differences in this process between CF and NCF cultures. Measurement(s) messenger RNA Technology Type(s) RNA sequencing Factor Type(s) exposure to flagellin • cystic fibrosis versus non-cystic fibrosis • mechanical wounding Sample Characteristic - Organism Homo sapiens Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.9944675 |
ArticleNumber | 240 |
Author | Zoso, Alice Bacchetta, Marc Sofoluwe, Aderonke Chanson, Marc |
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Cites_doi | 10.1513/pats.200605-126SF 10.1164/rccm.200410-1398OC 10.1038/ni.3045 10.1016/j.biocel.2014.02.010 10.1038/s41586-018-0394-6 10.1016/j.jcf.2018.03.010 10.1002/path.2118 10.1038/s41467-018-06768-z 10.1183/09031936.00221711 10.1007/978-1-61779-120-8_10 10.6084/m9.figshare.c.4638233 10.1038/nm.2715 10.1038/nature13173 10.1002/wdev.58 10.1152/ajpcell.00168.2013 10.1152/ajpcell.00215.2010 |
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SubjectTerms | 631/337/2019 631/80/85/2361 692/699/1785/3193 Bronchi - cytology Cells, Cultured Cystic fibrosis Cystic Fibrosis - genetics Data Descriptor Epithelial cells Epithelial Cells - metabolism Epithelium Flagellin Humanities and Social Sciences Humans multidisciplinary Respiratory tract Ribonucleic acid RNA Science Science (multidisciplinary) Transcriptome Wound healing Wounding |
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Title | Transcriptomic profile of cystic fibrosis airway epithelial cells undergoing repair |
URI | https://link.springer.com/article/10.1038/s41597-019-0256-6 https://www.ncbi.nlm.nih.gov/pubmed/31664037 https://www.proquest.com/docview/2310419867 https://search.proquest.com/docview/2310673596 https://pubmed.ncbi.nlm.nih.gov/PMC6820749 |
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