Allosteric modulation of a human protein kinase with monobodies - Zorba, Adelajda; Nguyen, Vy; Koide, Akiko; Hoemberger, Marc; Zheng, Yuejiao; Kutter, Steffen; Kim, Chansik; Koide, Shohei; Kern, Dorothee (Proceedings of the National Academy of Sciences - PNAS, 2019)
Keywords: 60 APPLIED LIFE SCIENCES; Adenosine Triphosphate - chemistry; Adenosine Triphosphate - metabolism; allosteric drugs; Allosteric properties; Allosteric Regulation - genetics; allostery; Aurora A; Aurora Kinase A - antagonists & inhibitors; Aurora Kinase A - chemistry; Aurora Kinase A - genetics; Aurora Kinase B - antagonists & inhibitors; Aurora Kinase B - chemistry; Aurora Kinase B - genetics; Binding sites; Binding Sites - genetics; Biological Sciences; Carrier Proteins - chemistry; Carrier Proteins - genetics; Crystal structure; Crystallography, X-Ray; Drug delivery; Drug Design; Drug development; Fibronectin Type III Domain - genetics; Humans; kinase; Kinases; Modulation; Modulators; monobody; Physical Sciences; Protein Conformation; Protein kinase; Protein Kinase Inhibitors - chemistry; Protein Kinases - chemistry; Protein Kinases - genetics; science & technology - other topics; Selectivity; kinase; monobody; Aurora A; allosteric drugs; allostery