The PD-1/PD-L1 Inhibitory Pathway is Altered in Primary Glomerulonephritides

• Published in: Archivum Immunologiae et Therapiae Experimentalis Vol. 66; no. 2; pp. 133 - 143
• Main Authors: Grywalska, Ewelina, Smarz-Widelska, Iwona, Krasowska-Zajac, Ewelina, Korona-Glowniak, Izabela, Zaluska-Patel, Karolina, Mielnik, Michal, Podgajna, Martyna, Malm, Anna, Rolinski, Jacek, Zaluska, Wojciech
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2018; Springer Nature B.V
• Subjects: Adult; Antigens, CD19 - metabolism; Apoptosis; B-Lymphocytes - immunology; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Biomedical and Life Sciences; Biomedicine; CD19 antigen; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell activation; Cell death; Female; Flow Cytometry; Gene Expression Regulation; Glomerulonephritis - immunology; Glomerulonephritis - metabolism; Humans; Immunology; Immunophenotyping; Labeling; Lymphocyte Activation; Lymphocytes; Lymphocytes B; Lymphocytes T; Male; Middle Aged; Monoclonal antibodies; Original; Original Article; Pathogenesis; PD-1 protein; PD-L1 protein; Peripheral blood; Pharmacology/Toxicology; Programmed Cell Death 1 Receptor - genetics; Programmed Cell Death 1 Receptor - metabolism; Signal Transduction; Young Adult; Glomerulonephritis; Immunosuppression; Minimal change disease; Immunology; IgA nephropathy; Membranoproliferative glomerulonephritis

The pathogenesis of primary proliferative and non-proliferative glomerulonephritides (PGN and NPGN) is still not fully understood, however, current evidence suggests that most cases of PGN and NPGN are the results of immunologic response to different etiologic agents that activates various biologica...