Mechanisms underlying the radioprotective effect of histamine on small intestine

• Published in: International journal of radiation biology Vol. 83; no. 10; pp. 653 - 663
• Main Authors: Medina, Vanina A., Croci, Máximo, Mohamad, Nora A., Massari, Noelia, Garbarino, Gloria, Cricco, Graciela P., Núñez, Mariel A., Martín, Gabriela A., Crescenti, Ernesto J. V., Bergoc, Rosa M., Rivera, Elena S.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2007; Taylor & Francis
• Subjects: Animals; antioxidant enzymes; apoptosis; Apoptosis - drug effects; Cell Nucleus - pathology; Cell Proliferation - drug effects; Cesium Isotopes - metabolism; Cytoplasm - pathology; Edema - pathology; Histamine; Histamine - administration & dosage; Histamine - pharmacology; Immunohistochemistry; Injections, Subcutaneous; Intestinal Diseases - drug therapy; Intestinal Diseases - pathology; Intestinal Diseases - radiotherapy; Intestine, Small - drug effects; Intestine, Small - pathology; Intestine, Small - radiation effects; ionizing radiation; Mice; Mice, Nude; Peroxidases - metabolism; Proliferating Cell Nuclear Antigen - metabolism; Radiation Injuries, Experimental - drug therapy; Radiation Injuries, Experimental - prevention & control; Radiation Injuries, Experimental - veterinary; radioprotectant; small intestine; Time Factors; Whole-Body Irradiation

Purpose: To examine the protective effects of histamine on intestinal damage produced by gamma-radiation. Materials and methods: 56 mice were divided into 4 groups. Histamine and Histamine-10 Gy groups received a daily subcutaneous histamine injection (0.1 mg kg) starting 20 hours before irradiation...