Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

• Published in: Acta cirurgica brasileira Vol. 30; no. 12; pp. 791 - 798
• Main Authors: Sousa, Rayssilane Cardoso de, Maia Filho, Antônio Luiz Martins, Nicolau, Renata Amadei, Mendes, Lianna Martha Soares, Barros, Talvany Luis de, Neves, Silvana Maria Véras
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01.12.2015
• Subjects: Analysis of Variance; Animals; Fibroblasts - pathology; Fibroblasts - radiation effects; Inflammation - pathology; Inflammation - radiotherapy; Lasers, Gas; Low-Level Light Therapy - methods; Male; Mice; Models, Animal; Ozone; Ozone - therapeutic use; Radiation Dosage; Random Allocation; Skin; Skin - injuries; Skin - pathology; Skin - radiation effects; Time Factors; Wound Healing; Wound Healing - radiation effects
• ISSN: 0102-8650; 1678-2674; 0102-8650
• DOI: 10.1590/S0102-865020150120000001

To evaluate in a macroscopic, histological and histomorphometric manner the healing process of cutaneous wounds in mice. The sample consisted of 40 male mice and was divided in four groups: 1st group (control, n=10), 2nd group (High Frequency Generator - HF, the maximum amplitude range, 120s, n=10), 3rd group (AlGaInP Laser 660 nm, 30mW power, 5 J/cm2, applying scan mode, 120s, n=10) and 4thgroup (AlGaInP Laser 660 nm, 30 mW power, 8 J/cm2, applying scan mode, n=10). The surgical incision was made with an 8 mm diameter punch perpendicularly to the back of the animal. The statistical analysis was achieved by the statistical test One Way Anova post hoc Tukey Test and significance at p<0.05 in GraphPad Prism program. It was observed that in the acute phase the AlGaInP Laser at 5 J/cm2 provided a greater stimulus to healing, and both lasers were effective in the remodeling phase. The AlGaInP lasers from 5 J/cm2 to 8 J/cm2 showed better biomodulatory results in the acute and remodeling phases respectively, however, the HF was less effective than the laser, providing significant benefits only in the acute phase of tissue repair.