Impact of pre-existing comorbidities and multimorbidities, demography and viral variants on post-acute sequelae of COVID-19 (‘Long COVID’) in Dutch primary care: A retrospective cohort study

• Published in: International journal of infectious diseases Vol. 156; p. 107912
• Main Authors: Berends, Matthijs S., Homburg, Maarten, Kupers, Thijmen, Meijer, Eline N., Bos, Isabelle, Verheij, Robert, Kuiper, Jeroen, Berger, Marjolein Y., Peters, Lilian L.
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.07.2025; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Comorbidities; Comorbidity; COVID-19 - complications; COVID-19 - epidemiology; COVID-19 - virology; Electronic Health Records; Female; General practitioners; Humans; Long COVID; Male; Middle Aged; Multimorbidity; Netherlands - epidemiology; PASC; Post-Acute COVID-19 Syndrome; Post-acute sequelae of COVID-19; Post-COVID; Prevalence; Primary Health Care - statistics & numerical data; Retrospective Studies; Risk Factors; SARS-CoV-2 - genetics; Young Adult; Netherlands; Post-COVID; Post-acute sequelae of COVID-19; PASC; Comorbidities; Long COVID; General practitioners

•PASC prevalence was 5.8% in a large primary care cohort of 19,638 COVID-19 cases.•Conditions like lung and cardiovascular disease, and diabetes increase PASC risk.•Women and individuals aged 45+ are at higher risk of developing prolonged PASC.•Combined mental illness and lung disease increase risk...