ZFHX3 is indispensable for ERβ to inhibit cell proliferation via MYC downregulation in prostate cancer cells

• Published in: Oncogenesis (New York, NY) Vol. 8; no. 4; p. 28
• Main Authors: Hu, Qingxia, Zhang, Baotong, Chen, Rui, Fu, Changying, A, Jun, Fu, Xing, Li, Juan, Fu, Liya, Zhang, Zhiqian, Dong, Jin-Tang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.04.2019; Nature Publishing Group
• Subjects: 13/1; 13/109; 13/89; 38/22; 38/23; 38/90; 631/67/589/466; 631/80; 82/80; Androgen receptors; Apoptosis; Cell Biology; Cell growth; Cell proliferation; Epithelial cells; Estrogen receptors; Homeobox; Human Genetics; Internal Medicine; Medicine; Medicine & Public Health; Myc protein; Oncology; Prostate cancer; Transcription; Tumor cell lines; Tumor suppressor genes; Tumorigenesis; Zinc finger proteins

Both estrogen receptor 2 (ESR2, also known as estrogen receptor beta (ERβ)) and the zinc-finger homeobox 3 (ZFHX3, also known as ATBF1 for AT motif-binding factor 1) modulate prostate development and suppress prostatic tumorigenesis in mice. ZFHX3 is integral to proper functions of ESR1 (i.e., estro...