AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression

• Published in: Neuromolecular medicine Vol. 21; no. 1; pp. 25 - 32
• Main Authors: Hang, Liting, Thundyil, John, Goh, Geraldine W. Y., Lim, Kah-Leong
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2019; Springer Nature B.V
• Subjects: Animal models; Basal ganglia; Biomedical and Life Sciences; Biomedicine; Central nervous system diseases; Dopamine receptors; Energy balance; Etiology; Evolution; Homeostasis; Internal Medicine; Kinases; Mesencephalon; Metformin; Mitochondria; Movement disorders; Neurodegenerative diseases; Neurology; Neuroprotection; Neurosciences; Original Paper; Parkin protein; Parkinson's disease; Phenotypes; PTEN-induced putative kinase; Substantia nigra; Mitochondria; PINK1; PGC-1α; AMP kinase; Parkinson’s disease; Parkin

Parkinson’s disease (PD) is a prevalent neurodegenerative movement disorder that is characterized pathologically by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive research, the etiology of PD remains poorly understood...