Evaluating the Antioxidants, Whitening and Antiaging Properties of Rice Protein Hydrolysates
Plant-derived protein hydrolysates have potential applications in nutrition. Rice protein hydrolysates (RPHs), an excellent source of proteins, have attracted attention for the development of cosmeceuticals. However, few studies have reported the potential application of RPH in analysis, and this st...
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| Published in | Molecules (Basel, Switzerland) Vol. 26; no. 12; p. 3605 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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12.06.2021
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| Abstract | Plant-derived protein hydrolysates have potential applications in nutrition. Rice protein hydrolysates (RPHs), an excellent source of proteins, have attracted attention for the development of cosmeceuticals. However, few studies have reported the potential application of RPH in analysis, and this study examined their antioxidant activities and the inhibitory activities of skin aging enzymes. The results indicated that the total phenolic and flavonoid concentrations were 2.06 ± 0.13 mg gallic acid equivalent/g RPHs and 25.96 ± 0.52 µg quercetin equivalent/g RPHs, respectively. RPHs demonstrated dose-dependent activity for scavenging free radicals from 1,1-diphenyl-2-picrylhydrazyl [half-maximal inhibitory concentration (IC50) = 42.58 ± 2.1 mg/g RPHs] and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (IC50 = 2.11 ± 0.88 mg/g RPHs), dose-dependent reduction capacity (6.95 ± 1.40 mg vitamin C equivalent/g RPHs) and oxygen radical absorbance capacity (473 µmol Trolox equivalent/g RPHs). The concentrations of the RPH solution required to achieve 50% inhibition of hyaluronidase and tyrosinase activities were determined to be 8.91 and 107.6 mg/mL, respectively. This study demonstrated that RPHs have antioxidant, antihyaluronidase, and antityrosinase activities for future cosmetic applications. |
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| AbstractList | Plant-derived protein hydrolysates have potential applications in nutrition. Rice protein hydrolysates (RPHs), an excellent source of proteins, have attracted attention for the development of cosmeceuticals. However, few studies have reported the potential application of RPH in analysis, and this study examined their antioxidant activities and the inhibitory activities of skin aging enzymes. The results indicated that the total phenolic and flavonoid concentrations were 2.06 ± 0.13 mg gallic acid equivalent/g RPHs and 25.96 ± 0.52 µg quercetin equivalent/g RPHs, respectively. RPHs demonstrated dose-dependent activity for scavenging free radicals from 1,1-diphenyl-2-picrylhydrazyl [half-maximal inhibitory concentration (IC50) = 42.58 ± 2.1 mg/g RPHs] and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (IC50 = 2.11 ± 0.88 mg/g RPHs), dose-dependent reduction capacity (6.95 ± 1.40 mg vitamin C equivalent/g RPHs) and oxygen radical absorbance capacity (473 µmol Trolox equivalent/g RPHs). The concentrations of the RPH solution required to achieve 50% inhibition of hyaluronidase and tyrosinase activities were determined to be 8.91 and 107.6 mg/mL, respectively. This study demonstrated that RPHs have antioxidant, antihyaluronidase, and antityrosinase activities for future cosmetic applications. Plant-derived protein hydrolysates have potential applications in nutrition. Rice protein hydrolysates (RPHs), an excellent source of proteins, have attracted attention for the development of cosmeceuticals. However, few studies have reported the potential application of RPH in analysis, and this study examined their antioxidant activities and the inhibitory activities of skin aging enzymes. The results indicated that the total phenolic and flavonoid concentrations were 2.06 ± 0.13 mg gallic acid equivalent/g RPHs and 25.96 ± 0.52 µg quercetin equivalent/g RPHs, respectively. RPHs demonstrated dose-dependent activity for scavenging free radicals from 1,1-diphenyl-2-picrylhydrazyl [half-maximal inhibitory concentration (IC50) = 42.58 ± 2.1 mg/g RPHs] and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (IC50 = 2.11 ± 0.88 mg/g RPHs), dose-dependent reduction capacity (6.95 ± 1.40 mg vitamin C equivalent/g RPHs) and oxygen radical absorbance capacity (473 µmol Trolox equivalent/g RPHs). The concentrations of the RPH solution required to achieve 50% inhibition of hyaluronidase and tyrosinase activities were determined to be 8.91 and 107.6 mg/mL, respectively. This study demonstrated that RPHs have antioxidant, antihyaluronidase, and antityrosinase activities for future cosmetic applications.Plant-derived protein hydrolysates have potential applications in nutrition. Rice protein hydrolysates (RPHs), an excellent source of proteins, have attracted attention for the development of cosmeceuticals. However, few studies have reported the potential application of RPH in analysis, and this study examined their antioxidant activities and the inhibitory activities of skin aging enzymes. The results indicated that the total phenolic and flavonoid concentrations were 2.06 ± 0.13 mg gallic acid equivalent/g RPHs and 25.96 ± 0.52 µg quercetin equivalent/g RPHs, respectively. RPHs demonstrated dose-dependent activity for scavenging free radicals from 1,1-diphenyl-2-picrylhydrazyl [half-maximal inhibitory concentration (IC50) = 42.58 ± 2.1 mg/g RPHs] and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (IC50 = 2.11 ± 0.88 mg/g RPHs), dose-dependent reduction capacity (6.95 ± 1.40 mg vitamin C equivalent/g RPHs) and oxygen radical absorbance capacity (473 µmol Trolox equivalent/g RPHs). The concentrations of the RPH solution required to achieve 50% inhibition of hyaluronidase and tyrosinase activities were determined to be 8.91 and 107.6 mg/mL, respectively. This study demonstrated that RPHs have antioxidant, antihyaluronidase, and antityrosinase activities for future cosmetic applications. |
| Author | Chen, Cheng-You Zheng, Ji-Hong Lin, Yung-Sheng Fan, Siao-Ling Chau, Chi-Fai Huang, Yu-Chun Dai, Fan-Jhen Chen, Chin-Shuh Chen, Hui-Ju |
| AuthorAffiliation | 2 Healthmate Co., Ltd., Changhua City 500016, Taiwan; jane@healthmate.com.tw (F.-J.D.); eileen@healthmate.com.tw (S.-L.F.); tina@healthmate.com.tw (Y.-C.H.) 4 Department of Chemical Engineering, National United University, Miaoli 360001, Taiwan; U0714049@smail.nuu.edu.tw 3 Ph.D. Program in Materials and Chemical Engineering, National United University, Miaoli 360001, Taiwan; D0612002@smail.nuu.edu.tw 1 Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 402204, Taiwan; d103043004@mail.nchu.edu.tw (H.-J.C.); chaucf@nchu.edu.tw (C.-F.C.) 5 Institute of Food Safety and Health Risk Assessment, National Yang-Ming University, Taipei 112304, Taiwan |
| AuthorAffiliation_xml | – name: 5 Institute of Food Safety and Health Risk Assessment, National Yang-Ming University, Taipei 112304, Taiwan – name: 1 Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 402204, Taiwan; d103043004@mail.nchu.edu.tw (H.-J.C.); chaucf@nchu.edu.tw (C.-F.C.) – name: 2 Healthmate Co., Ltd., Changhua City 500016, Taiwan; jane@healthmate.com.tw (F.-J.D.); eileen@healthmate.com.tw (S.-L.F.); tina@healthmate.com.tw (Y.-C.H.) – name: 3 Ph.D. Program in Materials and Chemical Engineering, National United University, Miaoli 360001, Taiwan; D0612002@smail.nuu.edu.tw – name: 4 Department of Chemical Engineering, National United University, Miaoli 360001, Taiwan; U0714049@smail.nuu.edu.tw |
| Author_xml | – sequence: 1 givenname: Hui-Ju surname: Chen fullname: Chen, Hui-Ju – sequence: 2 givenname: Fan-Jhen surname: Dai fullname: Dai, Fan-Jhen – sequence: 3 givenname: Cheng-You surname: Chen fullname: Chen, Cheng-You – sequence: 4 givenname: Siao-Ling surname: Fan fullname: Fan, Siao-Ling – sequence: 5 givenname: Ji-Hong surname: Zheng fullname: Zheng, Ji-Hong – sequence: 6 givenname: Yu-Chun surname: Huang fullname: Huang, Yu-Chun – sequence: 7 givenname: Chi-Fai orcidid: 0000-0002-6761-7932 surname: Chau fullname: Chau, Chi-Fai – sequence: 8 givenname: Yung-Sheng orcidid: 0000-0002-9522-1812 surname: Lin fullname: Lin, Yung-Sheng – sequence: 9 givenname: Chin-Shuh surname: Chen fullname: Chen, Chin-Shuh |
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| SubjectTerms | Aging Amino acids antioxidant Antioxidants Calibration cosmetic Enzymes Free radicals hyaluronidase Lipid peroxidation Lipids Peptides Polyphenols Proteins Rice rice protein hydrolysate Skin tyrosinase |
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| Title | Evaluating the Antioxidants, Whitening and Antiaging Properties of Rice Protein Hydrolysates |
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