Di-n-butyl phthalate epigenetically induces reproductive toxicity via the PTEN/AKT pathway

• Published in: Cell death & disease Vol. 10; no. 4; p. 307
• Main Authors: Li, Ran, Xing, Qian-wei, Wu, Xiao-lu, Zhang, Lei, Tang, Min, Tang, Jing-yuan, Wang, Jing-zi, Han, Peng, Wang, Shang-qian, Wang, Wei, Zhang, Wei, Zhou, Guo-ping, Qin, Zhi-qiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.04.2019; Springer Nature B.V
• Subjects: 13/1; 13/109; 13/2; 13/31; 13/89; 45/91; 631/337/176/1988; 631/80/82/23; AKT protein; Animals; Antibodies; Apoptosis; Apoptosis - drug effects; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Line; Cell Proliferation - drug effects; Demethylation; Dibutyl Phthalate - toxicity; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA damage; DNA Damage - drug effects; DNA Demethylation; DNA methylation; DNA Methyltransferase 3B; Flagella; Flagella - genetics; Flagella - metabolism; Germ cells; Immunology; Life Sciences; Male; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; MicroRNAs - metabolism; n-Butyl phthalate; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - chemistry; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; PTEN protein; Reproductive system; Signal Transduction - drug effects; Sperm; Sperm Motility - drug effects; Sperm Motility - genetics; Spermatozoa - drug effects; Spermatozoa - metabolism; Testis - cytology; Testis - drug effects; Testis - metabolism; Toxicity

Di-n-butyl phthalate (DBP) is a kind of ubiquitous chemical linked to hormonal disruptions that affects male reproductive system. However, the mechanism of DBP-induced germ cells toxicity remains unclear. Here, we demonstrate that DBP induces reduction of proliferation, increase of apoptosis and DNA...