Dysfunction of the Glymphatic System as a Potential Mechanism of Perioperative Neurocognitive Disorders

Perioperative neurocognitive disorder (PND) frequently occurs in the elderly as a severe postoperative complication and is characterized by a decline in cognitive function that impairs memory, attention, and other cognitive domains. Currently, the exact pathogenic mechanism of PND is multifaceted an...

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Published inFrontiers in aging neuroscience Vol. 13; p. 659457
Main Authors Ren, Xuli, Liu, Shan, Lian, Chuang, Li, Haixia, Li, Kai, Li, Longyun, Zhao, Guoqing
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 07.06.2021
Frontiers Media S.A
Subjects
Aging
Alzheimer's disease
Anesthesia
Blood-brain barrier
Cognition
Cognitive ability
Cytokines
Delirium
glymphatic system
Immunological memory
Inflammation
Metabolites
Neurological diseases
Neuroscience
Neurotoxicity
Older people
Pathogenesis
perioperative neurocognitive disorders
postoperative cognitive dysfunction
postoperative complications
postoperative neuropathy
Proteins
Surgery
Tumor necrosis factor-TNF
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Summary:Perioperative neurocognitive disorder (PND) frequently occurs in the elderly as a severe postoperative complication and is characterized by a decline in cognitive function that impairs memory, attention, and other cognitive domains. Currently, the exact pathogenic mechanism of PND is multifaceted and remains unclear. The glymphatic system is a newly discovered glial-dependent perivascular network that subserves a pseudo-lymphatic function in the brain. Recent studies have highlighted the significant role of the glymphatic system in the removal of harmful metabolites in the brain. Dysfunction of the glymphatic system can reduce metabolic waste removal, leading to neuroinflammation and neurological disorders. We speculate that there is a causal relationship between the glymphatic system and symptomatic progression in PND. This paper reviews the current literature on the glymphatic system and some perioperative factors to discuss the role of the glymphatic system in PND.
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Edited by: Shereen Nizari, University College London, United Kingdom
Reviewed by: Humberto Mestre, University of Rochester, United States
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2021.659457