Deep Sequencing of Viral Genomes Provides Insight into the Evolution and Pathogenesis of Varicella Zoster Virus and Its Vaccine in Humans

• Published in: Molecular biology and evolution Vol. 31; no. 2; pp. 397 - 409
• Main Authors: Depledge, Daniel P., Kundu, Samit, Jensen, Nancy J., Gray, Eleanor R., Jones, Meleri, Steinberg, Sharon, Gershon, Anne, Kinchington, Paul R., Schmid, D. Scott, Balloux, Francois, Nichols, Richard A., Breuer, Judith
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2014
• Subjects: Alleles; Attenuation; Chicken pox; Discoveries; Evolution; Evolution, Molecular; Exanthema; Exanthema - virology; Gene sequencing; Genome, Viral; Genomes; Genotype; Genotypes; Haplotypes; Herpes zoster; Herpesvirus 3, Human - genetics; Herpesvirus 3, Human - pathogenicity; High-Throughput Nucleotide Sequencing; Humans; Hybridization; Immunization; Inoculation; Latency; Lesions; Molecular Sequence Data; Mutation; Mutation Rate; Pathogenesis; Phylogeny; Polymorphism, Single Nucleotide; Positive selection; Selection, Genetic; Skin - virology; Skin diseases; Skin lesions; Vaccines; Varicella; Varicella-zoster virus; Viral Vaccines - adverse effects; Viral Vaccines - genetics; Viruses; viral evolution; alphaherpesvirus; pathogenesis

Immunization with the vOka vaccine prevents varicella (chickenpox) in children and susceptible adults. The vOka vaccine strain comprises a mixture of genotypes and, despite attenuation, causes rashes in small numbers of recipients. Like wild-type virus, the vaccine establishes latency in neuronal ti...