The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance

• Published in: Cold Spring Harbor perspectives in biology Vol. 3; no. 3; p. a001800
• Main Authors: Dent, E. W., Gupton, S. L., Gertler, F. B.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.03.2011
• Subjects: Actins - metabolism; Animals; Axons - physiology; Cell Communication - physiology; Cell Movement - physiology; Cytoskeletal Proteins - physiology; Cytoskeleton - physiology; Cytoskeleton - ultrastructure; Growth Cones - physiology; Growth Cones - ultrastructure; Humans; Models, Biological; Second Messenger Systems - physiology

Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape change and locomotion. Over the past two decades, our knowledge of the many guidance cues, receptors, and downstream signal...