Exploratory study on the relationship between urinary sodium/potassium ratio, salt intake, and the antihypertensive effect of esaxerenone: the ENaK Study

• Published in: Hypertension Research Vol. 47; no. 4; pp. 835 - 848
• Main Authors: Katsuya, Tomohiro, Inobe, Yoshito, Uchiyama, Kazuaki, Nishikawa, Tetsuo, Hirano, Kunio, Kato, Mitsutoshi, Fukui, Toshiki, Hatta, Tsuguru, Iwasaki, Arata, Ishii, Hajime, Sugiura, Toshiyuki, Taguchi, Takashi, Tanabe, Ayumi, Sugimoto, Kotaro, Shimosawa, Tatsuo
• Format: Journal Article
• Language: English
• Published: England Springer Science and Business Media LLC 01.04.2024; Nature Publishing Group
• Subjects: Antihypertensives; Biomarkers; Clinical trials; Creatinine; Diabetes; Diuretics; Drug dosages; Hyperkalemia; Hypertension; Potassium; Salt; Sodium; Urine; Japan; Hypertension; Estimated 24-h urinary sodium excretion; Urinary sodium/potassium ratio; Esaxerenone; Mineralocorticoid receptor blocker

Excessive salt intake is one of the causes of hypertension, and reducing salt intake is important for managing the risk of hypertension and subsequent cardiovascular events. Esaxerenone, a mineralocorticoid receptor blocker, has the potential to exert an antihypertensive effect in hypertensive patie...