Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses

• Published in: Cell research Vol. 30; no. 5; pp. 376 - 392
• Main Authors: Hou, Siyuan, Li, Zongcheng, Zheng, Xiaona, Gao, Yun, Dong, Ji, Ni, Yanli, Wang, Xiaobo, Li, Yunqiao, Ding, Xiaochen, Chang, Zhilin, Li, Shuaili, Hu, Yuqiong, Fan, Xiaoying, Hou, Yu, Wen, Lu, Liu, Bing, Tang, Fuchou, Lan, Yu
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.05.2020; Nature Publishing Group
• Subjects: 13/1; 13/31; 13/51; 14/19; 631/136; 631/532/1542; 64/110; 64/60; Aorta; Biomedical and Life Sciences; CD44 antigen; Cell Biology; Computer applications; Coronary vessels; Developmental stages; Embryos; Endothelial cells; Hematopoietic stem cells; In vivo methods and tests; Life Sciences; Populations; Stem cell transplantation; Stem cells; Surface markers

Hematopoietic stem cells (HSCs) in adults are believed to be born from hemogenic endothelial cells (HECs) in mid-gestational embryos. Due to the rare and transient nature, the HSC-competent HECs have never been stringently identified and accurately captured, let alone their genuine vascular precurso...