Effects of Fatty Acid Amide Hydrolase Inhibitors Acute Administration on the Positive and Cognitive Symptoms of Schizophrenia in Mice

• Published in: Molecular neurobiology Vol. 56; no. 11; pp. 7251 - 7266
• Main Authors: Kruk-Slomka, Marta, Banaszkiewicz, Izabela, Slomka, Tomasz, Biala, Grazyna
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2019; Springer Nature B.V
• Subjects: 2-Arachidonoylglycerol; Adrenal glands; Amidohydrolases - antagonists & inhibitors; Amidohydrolases - metabolism; Anandamide; Animals; Avoidance Learning - drug effects; Benzamides - administration & dosage; Benzamides - pharmacology; Benzamides - therapeutic use; Benzodioxoles - administration & dosage; Benzodioxoles - pharmacology; Benzodioxoles - therapeutic use; Biomedical and Life Sciences; Biomedicine; Cannabinoid CB1 receptors; Cannabinoid CB2 receptors; Carbamates - administration & dosage; Carbamates - pharmacology; Carbamates - therapeutic use; Cell Biology; Cognition - drug effects; Cognitive ability; Dizocilpine; Dizocilpine Maleate - administration & dosage; Dizocilpine Maleate - pharmacology; Dizocilpine Maleate - therapeutic use; Endocannabinoid system; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Fatty acids; Fatty-acid amide hydrolase; Glutamic acid receptors (ionotropic); Hydrolase; Inhibitors; Injections; Ligands; Lipase; Locomotor activity; Male; Memory; Memory - drug effects; Mental disorders; Mice; Motor Activity - drug effects; N-Methyl-D-aspartic acid receptors; Neurobiology; Neurology; Neurosciences; Piperidines - administration & dosage; Piperidines - pharmacology; Piperidines - therapeutic use; Rodents; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - physiopathology; Schizophrenia-like symptoms; MK-801; FAAH; MAGL; Mice; Endocannabinoids

The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachid...