Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses

• Published in: Cellular & molecular immunology Vol. 17; no. 6; pp. 587 - 599
• Main Authors: Hilligan, Kerry L., Ronchese, Franca
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2020; Nature Publishing Group
• Subjects: 631/250/1619/554/1898; 631/250/21/1566; 631/250/2152/1566/2493; 631/250/2504/133/2505; Antibodies; Antigen presentation; Antigen-presenting cells; Antigens; Biomedical and Life Sciences; Biomedicine; CD4 antigen; Cell activation; Cell differentiation; Chemokines; Cytokines; Dendritic cells; Effector cells; Helper cells; Immunology; Interfaces; Ligands; Lymphocytes; Lymphocytes T; Medical Microbiology; Microbiology; Phenotypes; Review; Review Article; Toll-like receptors; Transcription; Vaccine; Th effector responses; dendritic cells; CD4+ T cells

Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules for naive T cell activation and expansion, dendritic cells are thought to also provide signals for the different...