Heterologous calcium-dependent inactivation of Orai1 by neighboring TRPV1 channels modulates cell migration and wound healing

• Published in: Communications biology Vol. 2; no. 1; p. 88
• Main Authors: Bastián-Eugenio, Carlos Ernesto, Bohórquez-Hernández, Arlette, Pacheco, Jonathan, Sampieri, Alicia, Asanov, Alexander, Ocelotl-Oviedo, Jose Pablo, Guerrero, Adán, Darszon, Alberto, Vaca, Luis
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.03.2019; Nature Publishing Group
• Subjects: 14/19; 14/33; 631/57; 631/80; 82/79; 9/74; 96/35; 96/63; Biology; Biomedical and Life Sciences; Calcium - metabolism; Calcium channels; Calcium influx; Calcium Signaling; Capsaicin receptors; Cell adhesion & migration; Cell membranes; Cell migration; Cell Movement - genetics; Cells, Cultured; Electrophysiological Phenomena; Gene Expression; Genes, Reporter; Humans; Life Sciences; Orai1 protein; ORAI1 Protein - metabolism; Recombinant Fusion Proteins - metabolism; Thrombin; TRPV Cation Channels - metabolism; Wound Healing

Store-operated calcium entry (SOCE) is an essential calcium influx mechanism in animal cells. One of the most important auto regulatory control systems involves calcium-dependent inactivation (CDI) of the Orai channel, which prevents excessive calcium influx. In the present study we analyze the role...