A randomized, placebo-controlled, double-blinded pilot study of angiotensin 1–7 (TXA-127) for the treatment of severe COVID-19

An investigator-initiated new drug application (IND) was approved by the Food and Drug Administration (FDA), and the study was approved by the Columbia University Irving Medical Center (CUIMC) Institutional Review Board (IRB #AAAT0535). [...]morbidity and mortality improved by the time patients were...

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Published inCritical care (London, England) Vol. 26; no. 1; pp. 1 - 229
Main Authors Wagener, Gebhard, Goldklang, Monica P, Gerber, Adam, Elisman, Katerina, Eiseman, Katherine A, Fonseca, Laura D, D'Armiento, Jeanine M
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 28.07.2022
BioMed Central
BMC
Subjects
Angiotensin
Coronaviruses
Correspondence
COVID-19
Critical care
Drug therapy
Enzymes
FDA approval
Health aspects
Kidney diseases
Length of stay
Mortality
Pathophysiology
Polymerase chain reaction
Severe acute respiratory syndrome coronavirus 2
United States
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Abstract An investigator-initiated new drug application (IND) was approved by the Food and Drug Administration (FDA), and the study was approved by the Columbia University Irving Medical Center (CUIMC) Institutional Review Board (IRB #AAAT0535). [...]morbidity and mortality improved by the time patients were recruited into this study. [...]in this proof-of-concept study, TXA-127 was safe to administer in patients with severe COVID-19 infection.
AbstractList An investigator-initiated new drug application (IND) was approved by the Food and Drug Administration (FDA), and the study was approved by the Columbia University Irving Medical Center (CUIMC) Institutional Review Board (IRB #AAAT0535). [...]morbidity and mortality improved by the time patients were recruited into this study. [...]in this proof-of-concept study, TXA-127 was safe to administer in patients with severe COVID-19 infection.
ArticleNumber 229
Audience Academic
Author Wagener, Gebhard
Gerber, Adam
Elisman, Katerina
D'Armiento, Jeanine M
Goldklang, Monica P
Fonseca, Laura D
Eiseman, Katherine A
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CitedBy_id crossref_primary_10_17816_PED14198_118
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Cites_doi 10.1007/s00280-013-2089-x
10.1113/expphysiol.2011.056994
10.1164/rccm.200912-1840OC
10.1002/jmv.26254
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References C Schindler (4096_CR3) 2007; 3
V Shenoy (4096_CR4) 2010; 182
Y Qi (4096_CR2) 2011; 96
SP Singh (4096_CR1) 2021; 93
H Pham (4096_CR5) 2013; 71
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  start-page: 125
  issue: 1
  year: 2007
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  publication-title: Vasc Health Risk Manag
  contributor:
    fullname: C Schindler
– volume: 71
  start-page: 965
  issue: 4
  year: 2013
  ident: 4096_CR5
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-013-2089-x
  contributor:
    fullname: H Pham
– volume: 96
  start-page: 863
  issue: 9
  year: 2011
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  publication-title: Exp Physiol
  doi: 10.1113/expphysiol.2011.056994
  contributor:
    fullname: Y Qi
– volume: 182
  start-page: 1065
  issue: 8
  year: 2010
  ident: 4096_CR4
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200912-1840OC
  contributor:
    fullname: V Shenoy
– volume: 93
  start-page: 275
  issue: 1
  year: 2021
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  publication-title: J Med Virol
  doi: 10.1002/jmv.26254
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SubjectTerms Angiotensin
Coronaviruses
Correspondence
COVID-19
Critical care
Drug therapy
Enzymes
FDA approval
Health aspects
Kidney diseases
Length of stay
Mortality
Pathophysiology
Polymerase chain reaction
Severe acute respiratory syndrome coronavirus 2
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Title A randomized, placebo-controlled, double-blinded pilot study of angiotensin 1–7 (TXA-127) for the treatment of severe COVID-19
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