Nrf2 signaling attenuates epithelial-to-mesenchymal transition and renal interstitial fibrosis via PI3K/Akt signaling pathways

• Published in: Experimental and molecular pathology Vol. 111; p. 104296
• Main Authors: Wang, Jun, Zhu, Haobo, Huang, Liqu, Zhu, Xiaojiang, Sha, Jintong, Li, Guogen, Ma, Geng, Zhang, Wei, Gu, Min, Guo, Yunfei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2019
• Subjects: Animals; Cadherins - genetics; Cadherins - metabolism; Disease Models, Animal; Epithelial-Mesenchymal Transition; Epithelial-to-mesenchymal transition; Fibronectins - genetics; Fibronectins - metabolism; Fibrosis - etiology; Fibrosis - metabolism; Fibrosis - pathology; Fibrosis - prevention & control; Kidney Diseases - etiology; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidney Diseases - prevention & control; Kidney fibrosis; Mice; Mice, Knockout; NF-E2-Related Factor 2 - physiology; Nrf2; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; Ureteral Obstruction - etiology; Ureteral Obstruction - metabolism; Ureteral Obstruction - pathology; Ureteral Obstruction - prevention & control; Nrf2; Epithelial-to-mesenchymal transition; Kidney fibrosis

Nrf2 constitutes a therapeutic reference point for renal fibrosis and chronic kidney diseases. Nrf2-related signaling pathways are recognized to temper endothelial-to-mesenchymal transition (EMT) in fibrotic tissue. Nevertheless, the mechanism by which Nrf2 mitigates renal interstitial fibrosis is i...