Novel loci for triglyceride/HDL-C ratio longitudinal change among subjects without T2D

• Published in: Journal of lipid research Vol. 66; no. 1; p. 100702
• Main Authors: Wang, Lihua, Wang, Siyu, Anema, Jason A., Moghaddam, Vaha A., Lu, Yanli, Lin, Shiow, Daw, E. Warwick, Kuipers, Allison L., Miljkovic, Iva, Brent, Michael, Patti, Gary J., Thygarajan, Bharat, Zmuda, Joseph M., Province, Michael A., An, Ping
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2025; American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Adult; Aged; aging; Cholesterol, HDL - blood; Cholesterol, HDL - genetics; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Female; Genetic Loci; Genome-Wide Association Study; genome-wide linkage scan; GWAS; Humans; insulin resistance; Longitudinal Studies; Male; Middle Aged; multiomics analyses; Polymorphism, Single Nucleotide; Triglycerides - blood; Triglycerides - genetics; genome-wide linkage scan; LOD; WGS; GWAS; multiomics analyses; IR; FOS; LLFS; MGI; QC; MAF; PC; TG; GWLS; SOLAR; ALFA; HLOD; LD; aging; insulin resistance; THR

Triglyceride (TG)/HDL-C ratio (THR) is a surrogate predictor of hyperinsulinemia. To identify novel genetic loci for THR change over time (ΔTHR), we conducted genome-wide association study (GWAS) and genome-wide linkage scan (GWLS) among nondiabetic Europeans from the Long Life Family Study (n = 1,3...