Long-Term Administration of Mifepristone (RU486): Clinical Tolerance During Extended Treatment of Meningioma

• Published in: Cancer investigation Vol. 24; no. 8; pp. 727 - 733
• Main Authors: Grunberg, Steven M., Weiss, Martin H., Russell, Christy A., Spitz, Irving M., Ahmadi, Jamshid, Sadun, Alfredo, Sitruk-Ware, Regine
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2006; Taylor & Francis
• Subjects: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Contraceptives, Oral, Synthetic - administration & dosage; Contraceptives, Oral, Synthetic - adverse effects; Female; Hormonal modulation; Humans; Male; Meningeal Neoplasms - drug therapy; Meningioma; Meningioma - drug therapy; Middle Aged; Mifepristone; Mifepristone - administration & dosage; Mifepristone - adverse effects; Treatment Outcome

Background: Mifepristone (RU486) is an oral antiprogestational and, to a lesser extent, antiglucocorticoid agent commonly used for short-term (single-day) therapy. However, treatment of neoplasms or chronic conditions will require long-term administration. Meningioma is a benign central nervous syst...