Evaluation of MiR-15a and MiR-16-1 as prognostic biomarkers in chronic lymphocytic leukemia

• Published in: Biomedicine & pharmacotherapy Vol. 92; pp. 864 - 869
• Main Authors: Braga, Tatiane Vieira, Evangelista, Fernanda Cristina Gontijo, Gomes, Lorena Caixeta, Araújo, Sérgio Schusterschitz da Silva, Carvalho, Maria das Graças, Sabino, Adriano de Paula
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.08.2017
• Subjects: Biomarkers; Biomarkers, Tumor - metabolism; Chronic lymphocytic leukemia; Humans; Internal Medicine; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Medical Education; microRNA; MicroRNAs - metabolism; miR-15a; miR-16-1; Models, Biological; Prognosis; Biomarkers; microRNA; Chronic lymphocytic leukemia; miR-15a; miR-16-1

Chronic lymphocytic leukemia (CLL) is a B lineage neoplasm, characterized by the accumulation of B lymphocytes of great longevity, and usually develops as a result of the inhibition of apoptosis. Clinical evolution is extremely variable amongst affected individuals with survival ranging from a few m...