Multimodal imaging of the tumor microenvironment and biological responses to immune therapy

• Published in: Biomedical microdevices Vol. 20; no. 4; p. 105
• Main Authors: Saucedo, Alexander M., De La Cerda, Jorge, Suami, Hiroo, Serda, Rita E.
• Format: Journal Article
• Language: English
• Published: New York Springer US 03.12.2018; Springer Nature B.V
• Subjects: Adenocarcinoma; Animal models; Biological activity; Biological and Medical Physics; Biomedical Engineering and Bioengineering; Biophysics; Blood vessels; Cancer; CD4 antigen; CD45 antigen; CD8 antigen; Cell density; Cytokines; Density; Electron microscopy; Engineering; Engineering Fluid Dynamics; Extracellular matrix; Fluorescence; Granulocyte colony-stimulating factor; Immune system; Inflammation; Interferon; Interleukin 10; Interleukin 12; Leukocytes; Lymphocytes; Lymphocytes T; Macrophages; Monocytes; Nanotechnology; Perfluorocarbons; Perfusion; Phenotypes; Suppressor cells; Therapy; Tumors; Vascular endothelial growth factor; computed tomography; Interleukin 12; Magnetic resonance imaging; Electron microscopy; Tumor vasculature

Beyond heterogeneous cancer cells, the tumor microenvironment includes stromal and immune cells, blood vessels, extracellular matrix and biologically active molecules. Abnormal signaling, uncontrolled proliferation and high interstitial pressure all contribute to a chaotic, non-hierarchical vascular...