Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats

• Published in: International journal of molecular sciences Vol. 24; no. 21; p. 15977
• Main Authors: Yu, Ying, Kim, Sang-Min, Park, Kyeongsoon, Kim, Hak Jun, Kim, Jae Gyoon, Kim, Sung Eun
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2023
• Subjects: Apoptosis; Arthritis; Carbon; Cartilage; cartilage degradation; Cytotoxicity; Drug dosages; Extracellular matrix; Health aspects; Hydrogen; icariin; Inflammation; Interleukins; Investigations; Kinases; Macrophages; nanodiamonds; Nanomaterials; Osteoarthritis; Proteins; RNA; Scanning electron microscopy; Spectrum analysis; tannic acid; Tumor necrosis factor; South Korea; Japan

In present study, icariin (ICA)/tannic acid (TA)-nanodiamonds (NDs) were prepared as follows. ICA was anchored to ND surfaces with absorbed TA (ICA/TA-NDs) and we evaluated their in vitro anti-inflammatory effects on lipopolysaccharide (LPS)-activated macrophages and in vivo cartilage protective eff...