Crosstalk between the Akt/mTORC1 and NF-κB signaling pathways promotes hypoxia-induced pulmonary hypertension by increasing DPP4 expression in PASMCs

• Published in: Acta pharmacologica Sinica Vol. 40; no. 10; pp. 1322 - 1333
• Main Authors: Li, Ying, Yang, Li, Dong, Liang, Yang, Zhi-wei, Zhang, Jing, Zhang, Sheng-li, Niu, Meng-jie, Xia, Jing-wen, Gong, Yi, Zhu, Ning, Zhang, Xiu-juan, Zhang, Yuan-yuan, Wei, Xiao-min, Zhang, You-zhi, Zhang, Peng, Li, Sheng-qing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2019; Nature Publishing Group
• Subjects: Activation; Administration, Oral; AKT protein; Animals; Bioinformatics; Biomedical and Life Sciences; Biomedicine; Cell Hypoxia - drug effects; Cell Survival - drug effects; Cells, Cultured; Computational Biology; Dipeptidyl Peptidase 4 - metabolism; Dipeptidyl-peptidase IV; Dipeptidyl-Peptidase IV Inhibitors - administration & dosage; Dipeptidyl-Peptidase IV Inhibitors - pharmacology; Disease Models, Animal; HEK293 Cells; Humans; Hypertension; Hypoxia; Immunoglobulins; Immunology; Immunoprecipitation; Internal Medicine; Kinases; Male; Mass spectrometry; Mass spectroscopy; Medical Microbiology; Muscles; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; NF-kappa B - antagonists & inhibitors; NF-kappa B - metabolism; NF-κB protein; Peptidase; Pharmacology/Toxicology; Phosphorylation; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - metabolism; Pulmonary arteries; Pulmonary artery; Pulmonary Artery - drug effects; Pulmonary Artery - metabolism; Pulmonary Artery - pathology; Pulmonary hypertension; Rapamycin; Rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; Sitagliptin Phosphate - administration & dosage; Sitagliptin Phosphate - pharmacology; Smooth muscle; TOR protein; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - metabolism; Transcription; Vaccine; Wound healing; Wound Healing - drug effects; DPP4; NF-κB; sitagliptin; pulmonary hypertension; mTORC1; pulmonary artery smooth muscle cells; IκB kinase

Abnormal wound healing by pulmonary artery smooth muscle cells (PASMCs) promotes vascular remodeling in hypoxia-induced pulmonary hypertension (HPH). Increasing evidence shows that both the mammalian target of rapamycin complex 1 (mTORC1) and nuclear factor-kappa B (NF-κB) are involved in the develo...