Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells

• Published in: Neurochemical research Vol. 43; no. 3; pp. 540 - 555
• Main Authors: Ho, Christabel Fung-Yih, Bon, Claire Poh-Ee, Ng, Yee-Kong, Herr, Deron R., Wu, Jui-Sheng, Lin, Teng-Nan, Ong, Wei-Yi
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2018; Springer Nature B.V
• Subjects: Acetylation; Acetylation - drug effects; Animals; Anxiety; Arachidonate 12-Lipoxygenase - metabolism; Arachidonate 15-Lipoxygenase - metabolism; Axonogenesis; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brain; Cell Biology; Cell Differentiation - drug effects; Cell Proliferation - drug effects; Central nervous system; Chromatin; Cognition; Differentiation; Docosahexaenoic acid; Docosahexaenoic Acids - metabolism; Epigenesis, Genetic - drug effects; Epigenetics; Event-related potentials; Gene expression; Histone acetyltransferase; Histone deacetylase; Histone Deacetylase Inhibitors - pharmacology; Histones - metabolism; Humans; Inhibition; Inhibitors; Lipoxygenase; Membranes; Metabolism; Metabolites; Mice; Neural Stem Cells - metabolism; Neuroblastoma; Neuroblastoma - metabolism; Neuroblasts; Neurochemistry; Neurology; Neurons; Neurons - metabolism; Neurosciences; Original Paper; Pain perception; Polyunsaturated fatty acids; Prefrontal cortex; Retinoic acid; Short term memory; Sodium; Sodium butyrate; Spatial memory; Trichostatin A; Epigenetic effects; Cerebral cortex; PUFA; Brain development; Alox15; Histone acetylation; DHA; Resolvin D1

The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is enriched in neural membranes of the CNS, and recent studies have shown a role of DHA metabolism by 15-lipoxygenase-1 (Alox15) in prefrontal cortex resolvin D1 formation, hippocampo-prefrontal cortical long-term-potentiation, spati...