Gain modulation of the middle latency cutaneous reflex in patients with chronic joint instability after ankle sprain
•We investigated the modulation of cutaneous reflexes in the lower limb muscles of subjects with ankle sprain and joint instability.•The cutaneous afferent pathway was modified in the subjects with chronic ankle instability after ankle sprain.•These new findings partly shed light on the problem of i...
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| Published in | Clinical neurophysiology Vol. 124; no. 7; pp. 1406 - 1413 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ireland Ltd
01.07.2013
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| Abstract | •We investigated the modulation of cutaneous reflexes in the lower limb muscles of subjects with ankle sprain and joint instability.•The cutaneous afferent pathway was modified in the subjects with chronic ankle instability after ankle sprain.•These new findings partly shed light on the problem of impaired ankle joint regulation in patients with chronic ankle instability.
To investigate the neural alteration of reflex pathways arising from cutaneous afferents in patients with chronic ankle instability.
Cutaneous reflexes were elicited by applying non-noxious electrical stimulation to the sural nerve of subjects with chronic ankle instability (n=17) and control subjects (n=17) while sitting. Electromyographic (EMG) signals were recorded from each ankle and thigh muscle. The middle latency response (MLR; latency: 70–120ms) component was analyzed.
In the peroneus longus (PL) and vastus lateralis (VL) muscles, linear regression analyses between the magnitude of the inhibitory MLR and background EMG activity showed that, compared to the uninjured side and the control subjects, the gain of the suppressive MLR was increased in the injured side. This was also confirmed by the pooled data for both groups. The degree of MLR alteration was significantly correlated to that of chronic ankle instability in the PL.
The excitability of middle latency cutaneous reflexes in the PL and VL is modulated in subjects with chronic ankle instability.
Cutaneous reflexes may be potential tools to investigate the pathological state of the neural system that controls the lower limbs in subjects with chronic ankle instability. |
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| AbstractList | To investigate the neural alteration of reflex pathways arising from cutaneous afferents in patients with chronic ankle instability.
Cutaneous reflexes were elicited by applying non-noxious electrical stimulation to the sural nerve of subjects with chronic ankle instability (n=17) and control subjects (n=17) while sitting. Electromyographic (EMG) signals were recorded from each ankle and thigh muscle. The middle latency response (MLR; latency: 70-120 ms) component was analyzed.
In the peroneus longus (PL) and vastus lateralis (VL) muscles, linear regression analyses between the magnitude of the inhibitory MLR and background EMG activity showed that, compared to the uninjured side and the control subjects, the gain of the suppressive MLR was increased in the injured side. This was also confirmed by the pooled data for both groups. The degree of MLR alteration was significantly correlated to that of chronic ankle instability in the PL.
The excitability of middle latency cutaneous reflexes in the PL and VL is modulated in subjects with chronic ankle instability.
Cutaneous reflexes may be potential tools to investigate the pathological state of the neural system that controls the lower limbs in subjects with chronic ankle instability. Highlights • We investigated the modulation of cutaneous reflexes in the lower limb muscles of subjects with ankle sprain and joint instability. • The cutaneous afferent pathway was modified in the subjects with chronic ankle instability after ankle sprain. • These new findings partly shed light on the problem of impaired ankle joint regulation in patients with chronic ankle instability. •We investigated the modulation of cutaneous reflexes in the lower limb muscles of subjects with ankle sprain and joint instability.•The cutaneous afferent pathway was modified in the subjects with chronic ankle instability after ankle sprain.•These new findings partly shed light on the problem of impaired ankle joint regulation in patients with chronic ankle instability. To investigate the neural alteration of reflex pathways arising from cutaneous afferents in patients with chronic ankle instability. Cutaneous reflexes were elicited by applying non-noxious electrical stimulation to the sural nerve of subjects with chronic ankle instability (n=17) and control subjects (n=17) while sitting. Electromyographic (EMG) signals were recorded from each ankle and thigh muscle. The middle latency response (MLR; latency: 70–120ms) component was analyzed. In the peroneus longus (PL) and vastus lateralis (VL) muscles, linear regression analyses between the magnitude of the inhibitory MLR and background EMG activity showed that, compared to the uninjured side and the control subjects, the gain of the suppressive MLR was increased in the injured side. This was also confirmed by the pooled data for both groups. The degree of MLR alteration was significantly correlated to that of chronic ankle instability in the PL. The excitability of middle latency cutaneous reflexes in the PL and VL is modulated in subjects with chronic ankle instability. Cutaneous reflexes may be potential tools to investigate the pathological state of the neural system that controls the lower limbs in subjects with chronic ankle instability. To investigate the neural alteration of reflex pathways arising from cutaneous afferents in patients with chronic ankle instability.OBJECTIVETo investigate the neural alteration of reflex pathways arising from cutaneous afferents in patients with chronic ankle instability.Cutaneous reflexes were elicited by applying non-noxious electrical stimulation to the sural nerve of subjects with chronic ankle instability (n=17) and control subjects (n=17) while sitting. Electromyographic (EMG) signals were recorded from each ankle and thigh muscle. The middle latency response (MLR; latency: 70-120 ms) component was analyzed.METHODSCutaneous reflexes were elicited by applying non-noxious electrical stimulation to the sural nerve of subjects with chronic ankle instability (n=17) and control subjects (n=17) while sitting. Electromyographic (EMG) signals were recorded from each ankle and thigh muscle. The middle latency response (MLR; latency: 70-120 ms) component was analyzed.In the peroneus longus (PL) and vastus lateralis (VL) muscles, linear regression analyses between the magnitude of the inhibitory MLR and background EMG activity showed that, compared to the uninjured side and the control subjects, the gain of the suppressive MLR was increased in the injured side. This was also confirmed by the pooled data for both groups. The degree of MLR alteration was significantly correlated to that of chronic ankle instability in the PL.RESULTSIn the peroneus longus (PL) and vastus lateralis (VL) muscles, linear regression analyses between the magnitude of the inhibitory MLR and background EMG activity showed that, compared to the uninjured side and the control subjects, the gain of the suppressive MLR was increased in the injured side. This was also confirmed by the pooled data for both groups. The degree of MLR alteration was significantly correlated to that of chronic ankle instability in the PL.The excitability of middle latency cutaneous reflexes in the PL and VL is modulated in subjects with chronic ankle instability.CONCLUSIONSThe excitability of middle latency cutaneous reflexes in the PL and VL is modulated in subjects with chronic ankle instability.Cutaneous reflexes may be potential tools to investigate the pathological state of the neural system that controls the lower limbs in subjects with chronic ankle instability.SIGNIFICANCECutaneous reflexes may be potential tools to investigate the pathological state of the neural system that controls the lower limbs in subjects with chronic ankle instability. |
| Author | Futatsubashi, Genki Tazoe, Toshiki Komiyama, Tomoyoshi Sasada, Shusaku |
| Author_xml | – sequence: 1 givenname: Genki surname: Futatsubashi fullname: Futatsubashi, Genki organization: The United Graduate School of Education, Tokyo Gakugei University, Tokyo, Japan – sequence: 2 givenname: Shusaku surname: Sasada fullname: Sasada, Shusaku organization: Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi, Japan – sequence: 3 givenname: Toshiki surname: Tazoe fullname: Tazoe, Toshiki organization: Department of Physical Medicine and Rehabilitation, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA – sequence: 4 givenname: Tomoyoshi surname: Komiyama fullname: Komiyama, Tomoyoshi email: komiyama@faculty.chiba-u.jp organization: The United Graduate School of Education, Tokyo Gakugei University, Tokyo, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23541471$$D View this record in MEDLINE/PubMed |
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| Keywords | Middle latency response Chronic ankle instability Cutaneous reflexes |
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| Snippet | •We investigated the modulation of cutaneous reflexes in the lower limb muscles of subjects with ankle sprain and joint instability.•The cutaneous afferent... Highlights • We investigated the modulation of cutaneous reflexes in the lower limb muscles of subjects with ankle sprain and joint instability. • The... To investigate the neural alteration of reflex pathways arising from cutaneous afferents in patients with chronic ankle instability. Cutaneous reflexes were... To investigate the neural alteration of reflex pathways arising from cutaneous afferents in patients with chronic ankle instability.OBJECTIVETo investigate the... |
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| SubjectTerms | Adult Analysis of Variance Ankle - physiopathology Chronic ankle instability Cutaneous reflexes Electric Stimulation Electromyography Female Functional Laterality Humans Joint Instability - etiology Male Middle latency response Neurology Reaction Time - physiology Reflex - physiology Regression Analysis Skin - innervation Sprains and Strains - complications Sprains and Strains - pathology Young Adult |
| Title | Gain modulation of the middle latency cutaneous reflex in patients with chronic joint instability after ankle sprain |
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